Severe Dementia Predicts Weight Loss by the Time of Death
| Autor: | Renata Elaine Paraizo Leite, Wilson Jacob-Filho, Lea T. Grinberg, Izabela Ono Adriazola, Aline Maria M. Ciciliati, Claudia K. Suemoto, Daniela Souza Farias-Itao, Carlos Augusto Pasqualucci, Ricardo Nitrini |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Aging
medicine.medical_specialty Clinical Dementia Rating Clinical Trials and Supportive Activities Clinical Sciences body mass index Autopsy Neurodegenerative Alzheimer's Disease 03 medical and health sciences 0302 clinical medicine Clinical Research Weight loss Internal medicine Epidemiology Acquired Cognitive Impairment medicine 2.1 Biological and endogenous factors Psychology Dementia Obesity 030212 general & internal medicine Aetiology Cognitive decline RC346-429 Nutrition Original Research business.industry aging Neurosciences Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD) cognitive decline medicine.disease Brain Disorders Neurology Severe dementia Neurological epidemiology Neurology. Diseases of the nervous system Neurology (clinical) weight loss medicine.symptom business Body mass index 030217 neurology & neurosurgery dementia |
| Zdroj: | Frontiers in Neurology, Vol 12 (2021) Frontiers in Neurology |
| ISSN: | 1664-2295 |
| DOI: | 10.3389/fneur.2021.610302 |
| Popis: | Background: Body mass index (BMI) in midlife is associated with dementia. However, the association between BMI and late-life obesity is controversial. Few studies have investigated the association between BMI and cognitive performance near the time of death using data from autopsy examination. We aimed to investigate the association between BMI and dementia in deceased individuals who underwent a full-body autopsy examination.Methods: Weight and height were measured before the autopsy exam. Cognitive function before death was investigated using the Clinical Dementia Rating (CDR) scale. The cross-sectional association between BMI and dementia was investigated using linear regression models adjusted for sociodemographic and clinical variables.Results: We included 1,090 individuals (mean age 69.5 ± 13.5 years old, 46% women). Most participants (56%) had a normal BMI (18.5–24.9 kg/m2), and the prevalence of dementia was 16%. Twenty-four percent of the sample had cancer, including 76 cases diagnosed only by the autopsy examination. Moderate and severe dementia were associated with lower BMI compared with participants with normal cognition in fully adjusted models (moderate: β = −1.92, 95% CI = −3.77 to −0.06, p = 0.042; severe: β = −2.91, 95% CI = −3.97 to −1.86, p < 0.001).Conclusion: BMI was associated with moderate and severe dementia in late life, but we did not find associations of BMI with less advanced dementia stages. |
| Databáze: | OpenAIRE |
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