Invasive sinonasal disease due to dematiaceous fungi in immunocompromised individuals: case report and review of the literature
| Autor: | Catherine Derber, Gonzalo Bearman, Kara Elam |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Microbiology (medical)
Adult medicine.medical_specialty Posaconazole Neutropenia medicine.medical_treatment Invasive sinonasal disease Immunocompromised Host Pharmacotherapy Fatal Outcome Ascomycota Pregnancy medicine Humans Pregnancy Complications Infectious Sinusitis Voriconazole business.industry Anemia Aplastic Immunosuppression Exserohilum species General Medicine medicine.disease Debulking Dermatology Surgery Fungal sinusitis Phaeohyphomycosis Infectious Diseases Mycoses Dematiaceous fungi Female Aplastic anemia business medicine.drug |
| Zdroj: | International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 14 |
| ISSN: | 1878-3511 |
| Popis: | SummaryInvasive dematiaceous fungal sinusitis is an uncommon and aggressive disease in immunocompromised individuals. We report a unique case of invasive Exserohilum sinusitis in a pregnant, immunocompromised woman. After treating the woman with pregnancy-induced aplastic anemia and invasive Exserohilum sinusitis and pulmonary disease, we performed a Medline/PubMed review of invasive dematiaceous fungal sinonasal disease in immunocompromised individuals. Twelve cases of proven and one case of probable invasive sinonasal dematiaceous fungal disease in immunocompromised patients are reported in the English-language literature. The majority of patients had underlying hematological conditions. The crude mortality was high, with over half of the patients dying from presumed complications of the underlying immunosuppression. Successful outcomes were associated with surgical debridement, aggressive antifungal use, and a reduction of immunosuppression. The optimal treatment for immunocompromised patients with invasive dematiaceous fungal disease is not known. The role of newer triazoles, posaconazole and voriconazole, appears promising, however more clinical data are needed. Definitive diagnosis requires tissue biopsy and successful treatment is associated with reduction of immunosuppression, aggressive surgical debulking, and systemic antifungal therapy. |
| Databáze: | OpenAIRE |
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