Biotin labelling of amines by polymer-assisted solution-phase synthesis
| Autor: | Andreas Link, Karen Wieking, Abolfasl Golisade, Conrad Kunick, Claudia Herforth |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Magnetic Resonance Spectroscopy
Polymers Organic Chemistry Clinical Biochemistry Biotin Pharmaceutical Science Biochemistry Chemical synthesis Mass Spectrometry Solutions chemistry.chemical_compound chemistry Labelling Drug Discovery Molecular Medicine Organic chemistry Amine gas treating Polystyrene Amines Chemoselectivity Protecting group Molecular Biology Linker |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 11:1783-1786 |
| ISSN: | 0960-894X |
| Popis: | An efficient and simple polymer-assisted approach has been developed to biotinylate multifunctional compounds bearing an amino functionality. Biotin was immobilized on aminomethylated polystyrene via the Kenner safety catch linker, activated and subsequently transferred to the amino function of the target compounds chemoselectively, thus avoiding protecting group operations. This approach holds potential for the introduction of spacer-modified biotin derivatives. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect