Immunoreactive T and Tn antigens in malignancy: role in carcinoma diagnosis, prognosis, and immunotherapy

Autor: Desai Pr
Rok vydání: 2000
Předmět:
Zdroj: Transfusion Medicine Reviews. 14:312-325
ISSN: 0887-7963
DOI: 10.1053/tmrv.2000.16229
Popis: T AND Tn SPECIFICITIES were associated with carcinoma for the first time by Springer and coworkers 1,2 a quarter of a century ago; however, these specificities were well known to transfusion medicine personnel several decades earlier. About 70 years ago, HiJbener, Thomsen, and Friedenreich reported that in vitro bacterial contamination of human blood may render red blood cells (RBCs) panagglutinable by one's own and all human sera, except those of infants, without visible change in the RaGs. 3,4 Almost 2 decades later, it was shown that RBCs, after exposure to influenza viruses, become agglutinable. 5 This acquired polyagglutinability became known as the (Hiibener)ThQmsen-Friedenreich phenomenon, or the T phenomenon, and was associated with errors in blood grouping. 3-6 This phenomenon is attributable to unmasking of a cryptantigen, the Thomsen (T) antigen, named by Friedenreich to honor his teacher, O. Thomsen. Other T specificities not related to the ThomsenFriedenreich phenomenon have been described in virology, bacteriology, and immunology. The term T for Thomsen-Friedenreich specificity precedes all these other 'T ' designations by decades and therefore should not be abandoned. The term T specificity does not categorize the nature of the molecule carrying this specificity; glycoproteins, glycolipids, and lipopolysaccharides all may carry the T specificity. Exposure of the T antigen is due to the enzymatic action of neuraminidase present in certain bacteria and viruses. 3,5 This enzyme, also known as the receptor destroying enzyme (RDE) or sialidase, 71~ releases terminal sialic acid and uncovers a masked
Databáze: OpenAIRE
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