BMP-7 versus BMP-2 for the treatment of long bone nonunion
| Autor: | Lior Shabtai, Janet D. Conway, Alexandra Bauernschub, Stacy C Specht |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male medicine.medical_specialty Humeral Fractures animal structures Adolescent Bone Morphogenetic Protein 7 Nonunion Long bone Bone Morphogenetic Protein 2 medicine.disease_cause Bone morphogenetic protein 2 Weight-bearing Weight-Bearing Young Adult medicine Humans Orthopedics and Sports Medicine Complication rate Child Aged Fracture Healing business.industry Middle Aged medicine.disease Weight bear Surgery Bone morphogenetic protein 7 Tibial Fractures medicine.anatomical_structure Additional Surgery Child Preschool Fractures Ununited embryonic structures Female business Femoral Fractures |
| Zdroj: | Orthopedics. 37(12) |
| ISSN: | 1938-2367 |
| Popis: | The authors compared the results of treating nonunion with either bone morphogenetic protein (BMP)-7 or BMP-2. Between 2001 and 2009, 214 limb segments were treated for nonunion with either BMP-7 or BMP-2 at the authors’ institution. Sixty-three subjects received 76 units of BMP-7. Radiographic healing occurred in 70% of limb segments at an average of 30 weeks after surgery, and 75% of limb segments were weight bearing at an average of 23 weeks after surgery. In 15.8%, persistent nonunion necessitated additional surgery. Average follow-up was 32 months. One hundred twelve subjects received 138 units of BMP-2. Radiographic healing occurred in 93% of limb segments at an average of 19 weeks after surgery, and 88% were weight bearing at an average of 15 weeks after surgery. In 6.25%, persistent nonunion necessitated additional surgery. Average follow-up was 17 months. Several significant differences were observed. Patients in both BMP-7 and BMP-2 groups were able to fully weight bear at an average of 23 and 15 weeks, respectively ( P P P Orthopedics. 2014; 37(12):e1049–e1057.] |
| Databáze: | OpenAIRE |
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