| Popis: |
As technology continues to gain strong footing in the medical sciences, the application of its principles to overcome drug formulation challenges and the presentation of selected potently useful drugs have been encouraged. In the study presented in this chapter, our team undertook to formulate a floating drug delivery system of theophylline hydrochloride using a synthetic polymer and then investigate the effect of polymer concentration on tablet buoyancy and drug release properties. Hydroxypropyl methylcellulose (HPMC) is the polymer used at different concentration of 15% (F1), 20% (F2) and 30% (F3) for three formulation batches of floating tablets. The method employed was wet granulation and sodium bicarbonate along with citric acid as the gas generating agent. The physical properties of the granules and the floating tablets were evaluated. Also, the physicomechanical properties, buoyancy and swelling characteristic of the tablet were determined. The drug release study was done as outlined in the USP I (basket method) for 8h in 900 ml 0.1N HCl at 50 rpm. Samples were withdrawn at a predetermined time and analysed using a UV spectrophotometer at of 271 nm wavelength. All obtained data were statistically analyzed by one-way analysis of variance (ANOVA). The differences between means were considered significant at P |
