Associations between probable REM sleep behavior disorder, olfactory disturbance, and clinical symptoms in Parkinson's disease: A multicenter cross-sectional study
| Autor: | Kazuo Kitagawa, Keisuke Suzuki, Yasuyuki Okuma, Mutsumi Iijima, Takashi Osada, Shigeru Nogawa, Koichi Hirata, Fumihito Yoshii, Nobutaka Hattori |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
0301 basic medicine Olfactory system Muscle Physiology Parkinson's disease Movement disorders Eye Movements Physiology Visual System Cross-sectional study Sensory Physiology Social Sciences REM Sleep Behavior Disorder Disease Olfaction Disorders Medical Conditions Mathematical and Statistical Techniques 0302 clinical medicine Japan Surveys and Questionnaires Medicine and Health Sciences Prevalence Psychology Medicine Biomechanics Cognitive Impairment Aged 80 and over Movement Disorders Multidisciplinary Cognitive Neurology Statistics Neurodegenerative Diseases Parkinson Disease Middle Aged Sensory Systems Neurology Physical Sciences Regression Analysis Female medicine.symptom Research Article Adult medicine.medical_specialty Cognitive Neuroscience Science Rapid eye movement sleep Research and Analysis Methods REM sleep behavior disorder 03 medical and health sciences Rating scale Internal medicine Humans Statistical Methods Aged Behavior business.industry Biology and Life Sciences medicine.disease Cross-Sectional Studies 030104 developmental biology Case-Control Studies Cognitive Science Physiological Processes Sleep Musculoskeletal Mechanics business Mathematics 030217 neurology & neurosurgery Neuroscience |
| Zdroj: | PLoS ONE, Vol 16, Iss 2, p e0247443 (2021) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Background Rapid eye movement sleep behavior disorder (RBD) and olfactory dysfunction are useful for early diagnosis of Parkinson’s disease (PD). RBD and severe olfactory dysfunction are also regarded as risk factors for cognitive impairment in PD. This study aimed to assess the associations between RBD, olfactory function, and clinical symptoms in patients with PD. Methods The participants were 404 patients with non-demented PD. Probable RBD (pRBD) was determined using the Japanese version of the RBD screening questionnaire (RBDSQ-J) and the RBD Single-Question Screen (RBD1Q). Olfactory function was evaluated using the odor identification test for Japanese. Clinical symptoms were evaluated using the Movement Disorder Society Revision of the Unified PD Rating Scale (MDS-UPDRS) parts I–IV. Results In total, 134 (33.2%) patients indicated a history of pRBD as determined by the RBD1Q and 136 (33.7%) by the RBDSQ-J based on a cutoff value of 6 points. Moreover, 101 patients were diagnosed as pRBD by both questionnaires, 35 by the RBDSQ-J only, and 33 by the RBD1Q only. The MDS-UPDRS parts I–III scores were significantly higher and disease duration significantly longer in the pRBD group. pRBD was significantly associated with male gender and the MDS-UPDRS part I score. The olfactory identification function was significantly reduced in the pRBD group. Conclusions About 33% of the patients with PD had pRBD based on the questionnaires, and both motor and non-motor functions were significantly decreased in these patients. These results suggest that more extensive degeneration occurred in patients with non-demented PD with RBD. |
| Databáze: | OpenAIRE |
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