Morphofunctional Characteristics of the Kidneys in Chronic Endotoxemia against the Background of Hyperthyroidism
| Autor: | G. A. Kovnatskaya, S. A. Kalashnikova, A. I. Shchogolev |
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| Rok vydání: | 2011 |
| Předmět: |
Male
endocrine system medicine.medical_specialty endocrine system diseases Apoptosis Kidney Hyperthyroidism General Biochemistry Genetics and Molecular Biology Nephropathy Internal medicine Animals Medicine business.industry Direct effects Thyroid Renal tissue General Medicine medicine.disease Endotoxemia Rats Endocrinology medicine.anatomical_structure Immunohistochemistry business Nephrosclerosis |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 151:761-763 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-011-1434-5 |
| Popis: | Simulation of chronic endotoxemia in rats leads to the development of nephropathy and nephrosclerosis. Kidney involvement was more pronounced in animals with endotoxemia developing against the background of hyperthyroidism. Direct effects of bacterial LPS and its secondary effects mediated through circulating LPO products under conditions of thyroid hormone excess caused damage to the renal tissue. Immunohistochemical studies demonstrated higher expression of apoptosis markers in nephrocytes of the proximal tubules in rats with hyperthyroidism. |
| Databáze: | OpenAIRE |
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