Associations of polymorphisms in the candidate genes for Alzheimer's disease BIN1, CLU, CR1 and PICALM with gestational diabetes and impaired glucose tolerance

Autor: K. Dvořáková, Josef Vcelak, Hana Vaňková, D. Vejražková, P Lukasova, Iva Holmerová, Gabriela Vacinova, Robert Rusina, M. Vaňková, O. Lischkova, Běla Bendlová
Rok vydání: 2016
Předmět:
0301 basic medicine
Adult
Candidate gene
medicine.medical_specialty
endocrine system diseases
Biology
Polymorphism
Single Nucleotide
White People
PICALM
Impaired glucose tolerance
03 medical and health sciences
0302 clinical medicine
Insulin resistance
Gene Frequency
Alzheimer Disease
Pregnancy
Risk Factors
Diabetes mellitus
Internal medicine
Glucose Intolerance
Genetics
medicine
Odds Ratio
Humans
Genetic Predisposition to Disease
Molecular Biology
Allele frequency
Alleles
Genetic Association Studies
Adaptor Proteins
Signal Transducing
Aged
Tumor Suppressor Proteins
nutritional and metabolic diseases
Type 2 Diabetes Mellitus
Genetic Variation
Nuclear Proteins
General Medicine
Middle Aged
medicine.disease
Gestational diabetes
Diabetes
Gestational
030104 developmental biology
Endocrinology
Clusterin
Diabetes Mellitus
Type 2
Monomeric Clathrin Assembly Proteins
Receptors
Complement 3b
Female
030217 neurology & neurosurgery
Zdroj: Molecular biology reports. 44(2)
ISSN: 1573-4978
Popis: Alzheimer’s disease (AD) is the most common type of dementia, with a prevalence that is rising every year. AD is associated with type 2 diabetes mellitus (T2DM) and insulin resistance, and is therefore sometimes called “type 3 diabetes mellitus”. The aim of this study was to examine whether the variants of some candidate genes involved in the development of AD, namely BIN1 (rs744373), CLU (rs11136000), CR1 (rs3818361), and PICALM (rs3851179), are related to several disorders of glucose metabolism—gestational diabetes (GDM), T2DM and impaired glucose tolerance (IGT). Our study included 550 women with former GDM and 717 control women, 392 patients with T2DM and 180 non-diabetic controls, and 117 patients with IGT and 630 controls with normal glucose tolerance. Genotyping analysis was performed using specially-designed TaqMan assays. No significant associations of the genetic variants rs744373 in BIN1, rs11136000 in CLU, or rs3818361 in CR1 were found with GDM, T2DM or IGT, but rs3851179 in PICALM was associated with an increased risk of GDM. The frequency of the AD risk-associated C allele was significantly higher in the GDM group compared to controls: OR 1.21; 95% CI (1.03–1.44). This finding was not apparent in T2DM and IGT; conversely, the C allele of the PICALM SNP was protective for IGT: OR 0.67; 95% CI (0.51–0.89). This study demonstrates an association between PICALM rs3851179 and GDM as well as IGT. However, elucidation of the possible role of this gene in the pathogenesis of GDM requires further independent studies.
Databáze: OpenAIRE
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