Adenosine A1Antagonism Attenuatesβ-adrenergic-resistant Sudden Hypoxic Cardiac Insufficiency
| Autor: | Erhe Gao, Lawrence de Garavilla, Justin L. Kaplan, William C. Dalsey, Michelle S. Victain |
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| Rok vydání: | 2005 |
| Předmět: |
Male
medicine.medical_specialty Cardiac output Cardiotonic Agents Heart Diseases Pilot Projects Adenosine A1 Receptor Antagonists Rats Sprague-Dawley Dobutamine Internal medicine Heart rate medicine Animals Hypoxia Dose-Response Relationship Drug business.industry Hemodynamics General Medicine Oxygenation Adrenergic beta-Agonists Hypoxia (medical) Aminophylline Survival Analysis Adenosine Rats Disease Models Animal Treatment Outcome Endocrinology Xanthines Acute Disease Emergency Medicine Cardiology medicine.symptom business Perfusion medicine.drug |
| Zdroj: | Academic Emergency Medicine. 12:389-395 |
| ISSN: | 1553-2712 1069-6563 |
| DOI: | 10.1197/j.aem.2005.02.006 |
| Popis: | OBJECTIVES In states such as hypoxia, shock, and cardiac arrest, compromised systemic oxygenation or perfusion appears to induce cardiac insufficiency that can be resistant to beta-adrenergic drugs. Elevated levels of adenosine may mediate such beta-adrenergic-resistant cardiac insufficiency via the adenosine A(1) receptor (A(1)AdoR). The objective of this study was to test the hypothesis that selective A(1)AdoR antagonism attenuates hypoxic cardiac insufficiency more efficaciously than beta(1)-adrenergic agonism or nonselective adenosine antagonism. METHODS Rats were paralyzed and ventilated to a pCO(2) level of 35-40 mm Hg. Ten minutes before hypoxia (inspired o(2) concentration = 5%), rats were treated intravenously with one of the following: 0.1 mg/kg BG-9719 (n = 9), 10 mg/kg NPC-205 (n = 10; BG-9719 and NPC-205 are selective A(1)AdoR antagonists, with durations of action of 30-60 minutes and 60-90 minutes, respectively), 10 mg/kg aminophylline (n = 12), 5 microg/kg/min dobutamine (n = 11), or control solutions. These drug doses maximized survival duration in dose-response studies. RESULTS Before hypoxia, cardiac work was increased more by aminophylline and dobutamine than by BG-9719. Mean (+/-SEM) duration of survival (in minutes) after hypoxia increased from |
| Databáze: | OpenAIRE |
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