Towards a multi-physics modelling framework for thrombolysis under the influence of blood flow

Autor: X. Yun Xu, Andris Piebalgs
Přispěvatelé: Engineering & Physical Science Research Council (EPSRC)
Rok vydání: 2015
Předmět:
Lysis
medicine.medical_treatment
CLOT LYSIS
THERAPY
Biochemistry
Tissue plasminogen activator
PERMEATION
DISSOLUTION
blood flow
Thrombolytic Therapy
Research Articles
MATHEMATICAL-MODEL
PLASMA
biology
Models
Cardiovascular
Thrombolysis
Mechanics
Thrombosis
DIFFUSION
Multidisciplinary Sciences
medicine.anatomical_structure
Tissue Plasminogen Activator
Science & Technology - Other Topics
Blood Flow Velocity
Biotechnology
medicine.drug
Artery
Thrombolysis
mathematical model
multiscale
fibrin
blood clot
diffusion
convection
thrombolysis
medicine.medical_specialty
General Science & Technology
Biomedical Engineering
Biophysics
Biological Transport
Active
Bioengineering
Fibrin
fibrin clot
FIBRIN NETWORK
Biomaterials
medicine
Humans
tPA
PLASMINOGEN-ACTIVATOR
Science & Technology
Blood flow
medicine.disease
TRANSPORT
Surgery
multiscale
biology.protein
Porous medium
mathematical model
Zdroj: Journal of the Royal Society Interface
ISSN: 1742-5662
1742-5689
DOI: 10.1098/rsif.2015.0949
Popis: Thrombolytic therapy is an effective means of treating thromboembolic diseases but can also give rise to life-threatening side effects. The infusion of a high drug concentration can provoke internal bleeding while an insufficient dose can lead to artery reocclusion. It is hoped that mathematical modelling of the process of clot lysis can lead to a better understanding and improvement of thrombolytic therapy. To this end, a multi-physics continuum model has been developed to simulate the dissolution of clot over time upon the addition of tissue plasminogen activator (tPA). The transport of tPA and other lytic proteins is modelled by a set of reaction–diffusion–convection equations, while blood flow is described by volume-averaged continuity and momentum equations. The clot is modelled as a fibrous porous medium with its properties being determined as a function of the fibrin fibre radius and voidage of the clot. A unique feature of the model is that it is capable of simulating the entire lytic process from the initial phase of lysis of an occlusive thrombus (diffusion-limited transport), the process of recanalization, to post-canalization thrombolysis under the influence of convective blood flow. The model has been used to examine the dissolution of a fully occluding clot in a simplified artery at different pressure drops. Our predicted lytic front velocities during the initial stage of lysis agree well with experimental and computational results reported by others. Following canalization, clot lysis patterns are strongly influenced by local flow patterns, which are symmetric at low pressure drops, but asymmetric at higher pressure drops, which give rise to larger recirculation regions and extended areas of intense drug accumulation.
Databáze: OpenAIRE
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