Layered double hydroxides for controlled fluoride release
| Autor: | Alexandre Almeida Júnior, Naile Roberta Lima dos Santos, Grazielle Emanuella de Souza dos Santos, Fábio Correia Sampaio, Ticiano Gomes do Nascimento, Isabel Cristina Celerino de Moraes Porto, Camila Braga Dornelas, Luciano Aparecido Meireles Grillo, J. L. G. Marinho, Johnnatan Duarte de Freitas, Irinaldo Diniz Basílio Júnior, Clarissiane Serafim Cardoso, Lucas Meili |
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| Rok vydání: | 2019 |
| Předmět: |
Thermogravimetric analysis
Materials science Scanning electron microscope Fluorine Compounds Nanoparticle engineering.material Dental Caries Hydrothermal circulation Nanomaterials chemistry.chemical_compound Fluorides Hydroxides Humans General Materials Science Layered double hydroxides RK1-715 Radiography Dental Digital Cariostatic Agents chemistry Dentistry engineering Hydroxide Clay Nanoparticles Fluoride Nuclear chemistry |
| Zdroj: | Brazilian Oral Research, Vol 35 (2021) Brazilian Oral Research v.35 2021 Brazilian Oral Research Sociedade Brasileira de Pesquisa Odontológica (SBPqO) instacron:SBPQO Brazilian Oral Research, Volume: 35, Article number: e104, Published: 19 NOV 2021 |
| ISSN: | 1807-3107 |
| Popis: | This study aims to develop a nano-sized fluoridated layered double hydroxide (LDH)-based release system via hydrothermal treatment for the controlled delivery of fluoride (F-) ions in the oral environment. The synthesis of conventional LDH-type (C-LDH) precursor nanomaterials was conducted using a co-precipitation method at constant pH, and the nanoparticulate-LDH (N-LDH) was synthesized by a hydrothermal procedure. Fluoride LDH (F-LDH) products were obtained through indirect synthesis using the precursor ion-exchange technique by varying the agitation time (2 and 24 h) and temperature (25 and 40 °C) to produce 12 material samples. The materials were characterized by energy dispersive x-ray, hexamethyldisilazane, digital radiography x-ray, Fourier-transform infrared, thermogravimetric analysis, and scanning electron microscopy. Additionally, the F-release kinetic profile was evaluated for 21 d in neutral and acid media with mathematical model analysis. Products with varying F-quantities were obtained, revealing specific release profiles. In general, there was a higher F-release in the acid medium, with emphasis on F-LDH-8. Fluoride-LDH and controlled fluoride delivery was successfully obtained, proving the potential of these nanomaterials as alternative anti-caries agents. |
| Databáze: | OpenAIRE |
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