Acute buspirone abolishes the expression of behavioral dopaminergic supersensitivity in mice
| Autor: | Roberto Frussa-Filho, F B Alcântara, Claudio Marcos Teixeira de Queiroz, A M L Yagüe, T Bibancos |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Male
Dyskinesia Drug-Induced medicine.medical_specialty Physiology medicine.drug_class Dopamine medicine.medical_treatment Immunology Intraperitoneal injection Biophysics Tardive dyskinesia Biochemistry Anxiolytic Buspirone Drug Hypersensitivity Mice Internal medicine medicine Haloperidol Animals Drug Interactions General Pharmacology Toxicology and Pharmaceutics lcsh:QH301-705.5 Dopaminergic supersensitivity lcsh:R5-920 Behavior Behavior Animal business.industry General Neuroscience Dopaminergic Cell Biology General Medicine medicine.disease Endocrinology Anti-Anxiety Agents lcsh:Biology (General) Dyskinesia Dopamine receptor Anesthesia Dopamine Antagonists Stereotyped Behavior medicine.symptom lcsh:Medicine (General) business Locomotion medicine.drug |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Volume: 35, Issue: 2, Pages: 237-242, Published: FEB 2002 Brazilian Journal of Medical and Biological Research, Vol 35, Iss 2, Pp 237-242 (2002) |
| ISSN: | 0100-879X |
| DOI: | 10.1590/s0100-879x2002000200013 |
| Popis: | Previous studies have shown that rats withdrawn from long-term treatment with dopamine receptor blockers exhibit dopaminergic supersensitivity, which can be behaviorally evaluated by enhanced general activity observed in an open-field. Recently, it has been reported that co-treatment with the non-benzodiazepine anxiolytic buspirone attenuates the development of haloperidol-induced dopaminergic supersensitivity measured by open-field behavior of rats. The aims of the present study were: 1) to determine, as previously reported for rats, if mice withdrawn from long-term neuroleptic treatment would also develop dopaminergic supersensitivity using open-field behavior as an experimental paradigm, and 2) to examine if acute buspirone administration would attenuate the expression of this behavioral dopaminergic supersensitivity. Withdrawal from long-term haloperidol treatment (2.5 mg/kg, once daily, for 20 days) induced a significant (30%) increase in ambulation frequency (i.e., number of squares crossed in 5-min observation sessions) but did not modify rearing frequency or immobility duration in 3-month-old EPM-M1 male mice observed in the open-field apparatus. Acute intraperitoneal injection of buspirone (3.0 and 10 but not 1.0 mg/kg, 12-13 animals per group) 30 min before open-field exposure abolished the increase in locomotion frequency induced by haloperidol withdrawal. These data suggest that the open-field behavior of mice can be used to detect dopaminergic supersensitivity, whose expression is abolished by acute buspirone administration. |
| Databáze: | OpenAIRE |
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