Sequencing and analysis of chromosome 1 of Eimeria tenella reveals a unique segmental organization
| Autor: | Arnaud Kerhornou, Tiago José Pascoal Sobreira, Mohd Noor Mat Isa, M W Shirley, Marie Adele Rajandream, King Hwa Ling, Soon Joo Yap, Wai Y. Yee, Kiew Lian Wan, Karen Mungall, Sarah E. White, Alan Mitchell Durham, Damer P. Blake, Mariana Nor Shamsudin, Michael A. Quail, Arthur Gruber, Rozita Rosli, Alasdair Ivens, Pierre Rivailler, Shu S. Loo, Rahmah Mohamed, Xikun Wu, Fionnadh Carroll, Siew F. Wai, Fiona M. Tomley, Alan T. Bankier, Paul H. Dear, Jeniffer Novaes, Matthew Berriman, Karen J. Billington, Nick T. Peters, Alda Maria Backx Noronha Madeira, Adrian Tivey |
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| Rok vydání: | 2007 |
| Předmět: |
Letter
Genes Protozoan Molecular Sequence Data Virulence Minisatellite Repeats Plasmodium Eimeria Apicomplexa parasitic diseases Genetics medicine Parasite hosting Animals Gene Genetics (clinical) biology Base Sequence Chromosome Chromosome Mapping Computational Biology Sequence Analysis DNA biology.organism_classification medicine.disease Coccidiosis Chromosome Structures EIMERIA TENELLA Eimeria tenella Polymorphism Restriction Fragment Length |
| Zdroj: | Repositório Institucional da USP (Biblioteca Digital da Produção Intelectual) Universidade de São Paulo (USP) instacron:USP |
| Popis: | Eimeria tenella is an intracellular protozoan parasite that infects the intestinal tracts of domestic fowl and causes coccidiosis, a serious and sometimes lethal enteritis. Eimeria falls in the same phylum (Apicomplexa) as several human and animal parasites such as Cryptosporidium, Toxoplasma, and the malaria parasite, Plasmodium. Here we report the sequencing and analysis of the first chromosome of E. tenella, a chromosome believed to carry loci associated with drug resistance and known to differ between virulent and attenuated strains of the parasite. The chromosome—which appears to be representative of the genome—is gene-dense and rich in simple-sequence repeats, many of which appear to give rise to repetitive amino acid tracts in the predicted proteins. Most striking is the segmentation of the chromosome into repeat-rich regions peppered with transposon-like elements and telomere-like repeats, alternating with repeat-free regions. Predicted genes differ in character between the two types of segment, and the repeat-rich regions appear to be associated with strain-to-strain variation. |
| Databáze: | OpenAIRE |
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