Efficacy of temporal lobe surgery for epilepsy in patients with negative MRI for mesial temporal lobe sclerosis
| Autor: | William O. Tatum, Selim R. Benbadis, Katheryne Downes, Carlos Martinez, Nicolas Arredondo, Ali Bozorg, Kondi Wong, Fernando L. Vale, Euclides Effio |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Temporal lobe Epilepsy Temporal lobe seizure Physiology (medical) medicine Humans Ictal Epilepsy surgery Prospective Studies Aged Sclerosis medicine.diagnostic_test business.industry Magnetic resonance imaging General Medicine Middle Aged Anterior Temporal Lobectomy Prognosis Engel classification medicine.disease Magnetic Resonance Imaging Temporal Lobe medicine.anatomical_structure Epilepsy Temporal Lobe Neurology Scalp Anesthesia Brain Damage Chronic Female Surgery Neurology (clinical) business |
| Zdroj: | Journal of Clinical Neuroscience. 19:101-106 |
| ISSN: | 0967-5868 |
| Popis: | Epilepsy surgery is a successful treatment for refractory temporal lobe epilepsy (TLE). Reports suggest fewer seizure-free outcomes for patients with TLE and who have a negative brain MRI (nMRI) for mesial temporal sclerosis. Data were collected prospectively from patients with nMRI who underwent temporal lobe surgery for TLE characterized by unilateral ictal temporal lobe seizure onset based on a scalp video electroencephalogram or invasive subdural electrode recordings. A total of 86 patients were followed for at least 24 months after surgery. Outcome was evaluated using the Engel classification. Seizure control was obtained by 55% (47/86) of patients (Class [CL]-I), 27% (23/86) showed significant improvement (CL-II) and 19% (16/86) were deemed surgical failures. Shorter duration of epilepsy, later onset of seizures, and ictal theta rhythm (5-7 Hz) were the most significant predictors of postoperative seizure control. Although hypometabolism on positron emission tomography scan and significant memory disparity (>2.5/8) were not significant prognosticators independently, cumulatively they were predictors for favorable outcome. |
| Databáze: | OpenAIRE |
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