Reproductive evaluations in female rat offspring exposed to metformin during intrauterine and intrauterine/lactational periods
| Autor: | Daniela Cristina Ceccatto Gerardin, Graziela S. Ceravolo, Daniella R. B. S. Novi, Simone Forcato, Bruno Garcia Montagnini, Maria Luiza Marino de Góes, Ana Carolina Inhasz Kiss |
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| Přispěvatelé: | Universidade Estadual de Londrina (UEL), Seo Paulo State Univ, Universidade Estadual Paulista (Unesp) |
| Rok vydání: | 2019 |
| Předmět: |
endocrine system
medicine.medical_specialty Offspring Estrous Cycle 010501 environmental sciences Antidiabetic drug Toxicology 01 natural sciences 03 medical and health sciences Pregnancy Internal medicine Lactation medicine Animals Hypoglycemic Agents Sexual Maturation Androstenedione Rats Wistar Maternal Behavior Maternal-Fetal Exchange 030304 developmental biology 0105 earth and related environmental sciences Estrous cycle 0303 health sciences Behavior Animal Estradiol business.industry Ovary Uterus medicine.disease Metformin Gestational diabetes Fertility Endocrinology medicine.anatomical_structure Theca Prenatal Exposure Delayed Effects Gestation Maternal exposure Female business medicine.drug |
| Zdroj: | Web of Science Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| ISSN: | 0890-6238 |
| Popis: | Made available in DSpace on 2019-10-04T13:15:54Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-08-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Metformin (MET) is a widely-used drug for the treatment of type 2 diabetes mellitus and gestational diabetes. It is known that metformin crosses the placenta and can to be transferred through milk. In vitro studies show that MET decreases gonadotropin-releasing hormone and gonadotropins release in rat neurons, and decreases progesterone and estradiol in rat granulosa cells and androstenedione synthesis in human theca cells. This study evaluated whether MET maternal exposure might interfere with reproductive parameters of female offspring. Wistar female rats were treated with MET 293 mg/kg/day, by gavage, from gestational day (GD) 0 to GD 21 (METG) or GD 0 until lactation day (LD) 21 (METGL). Controls groups received water. An increase in plasmatic estradiol levels was observed during the estrus stage in the METGL group. This result suggests that exposure to MET during gestational and lactational periods might be related to programming in theca and/or granulosa cells during development. Univ Estadual Londrina, Ctr Biol Sci, Dept Physiol Sci, Londrina, PR, Brazil Seo Paulo State Univ, Dept Physiol, Botucatu, SP, Brazil |
| Databáze: | OpenAIRE |
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