PI3K pathway in prostate cancer: All resistant roads lead to PI3K
Autor: | Young Sik Kim, Davis Yeon Kim, Soonbum Park, Insuk So, Ju Hong Jeon |
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Rok vydání: | 2018 |
Předmět: |
0301 basic medicine
Male Cancer Research Cancer therapy 03 medical and health sciences Prostate cancer Phosphatidylinositol 3-Kinases 0302 clinical medicine Genetics medicine Animals Humans Epigenetics PI3K/AKT/mTOR pathway Cell survival business.industry Biological fitness Prostatic Neoplasms medicine.disease 030104 developmental biology Oncology Drug Resistance Neoplasm 030220 oncology & carcinogenesis Cancer research business Signal Transduction |
Zdroj: | Biochimica et biophysica acta. Reviews on cancer. 1870(2) |
ISSN: | 1879-2561 |
Popis: | The phosphoinositide 3-kinase (PI3K) pathway integrates multifarious environmental cues to regulate cell survival, growth, and metabolism. Hyperactivation of the PI3K pathway increases biological fitness by offering a high degree of adaptability to and resilience against diverse perturbations, thus conferring survival benefits on premalignant and transformed cells. In prostate cancer, the PI3K pathway is aberrantly activated by various genetic and epigenetic alterations and its hyperactivation is closely associated with a poor clinical outcome. In this review, we discuss the challenges encountered with clinically effective therapies targeting the PI3K pathway in prostate cancer, highlighting the clinical importance of combination therapies. In particular, we address how prostate cancer cells utilize the PI3K pathway for the development of resistance to a broad range of anticancer treatments. In addition, we describe the molecular mechanisms by which prostate cancer cells become resistant to PI3K pathway inhibitors. This review will be helpful in translating biological knowledge into therapeutic strategies for the treatment of prostate cancer and provide insight into overcoming therapeutic challenges associated with prostate cancer. |
Databáze: | OpenAIRE |
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