High-Density Lipoprotein Cholesterol and All-Cause and Cause-Specific Mortality Among the Elderly
| Autor: | Xiaoming Shi, Fu Rong Li, Zhi-Hao Li, Yue Bin Lv, Meng Chen Zou, Virginia B. Kraus, Xiang Gao, Jinqiu Yuan, Chen Mao, Xi Ru Zhang, Wen Fang Zhong, Xian Bo Wu |
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| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty Endocrinology Diabetes and Metabolism Clinical Biochemistry Context (language use) 030204 cardiovascular system & hematology Biochemistry 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Endocrinology High-density lipoprotein Risk Factors Cause of Death Internal medicine Humans Medicine Prospective Studies 030212 general & internal medicine Prospective cohort study Aged Proportional Hazards Models Cause of death Aged 80 and over business.industry Proportional hazards model Cholesterol Cholesterol HDL Biochemistry (medical) Hazard ratio Health and Retirement Study chemistry Cardiovascular Diseases Female business |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 104:3370-3378 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | The patterns of the association between high-density lipoprotein cholesterol (HDL-C) concentrations and mortality among the elderly are still unclear.To examine the association of HDL-C concentrations with mortality and to identify the optimal HDL-C concentration range that predicts the lowest risk of all-cause mortality among the elderly.This was a nationwide, community-based, prospective cohort study.This study included 7766 elderly individuals (aged ≥65 years; mean age: 74.4 years) from the Health and Retirement Study. Cox proportional hazards models and Cox models with penalized smoothing splines were used to estimate hazard ratios (HRs) with 95% CI for all-cause and cause-specific mortality.During a median follow-up of 5.9 years, 1921 deaths occurred. After a full adjustment for covariates, a nonlinear (P0.001 for nonlinearity) association was found between HDL-C and all-cause mortality [minimum mortality risk at 71 mg/dL (1.84 mM)]; the risk for all-cause mortality was significantly higher in the groups with HDL-C concentration61 mg/dL (1.58 mM; HR: 1.18; 95% CI: 1.05 to 1.33) and with HDL-C concentration87 mg/dL (2.25 mM; HR: 1.56; 95% CI: 1.17 to 2.07) than in the group with HDL-C concentrations ranging from 61 to 87 mg/dL (1.58 to 2.25 mM). Nonlinear associations of HDL-C concentrations with both cardiovascular and noncardiovascular mortality were also observed (both P0.001 for nonlinearity).Among the elderly, nonlinear associations were found between HDL-C and all-cause and cardiovascular mortality. The single optimal HDL-C concentration and range were 71 mg/dL and 61 to 87 mg/dL, respectively. |
| Databáze: | OpenAIRE |
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