Influence of moclobemide on cognitive functions of nine depressed patients: Pilot trial with neurophysiological and neuropsychological indices
| Autor: | Armida Mucci, Silvana Galderisi, Paola Bucci, Maria Laura Mignone, Mario Maj |
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| Přispěvatelé: | Galderisi, Silvana, Mucci, Armida, Bucci, Paola, Mignone, Ml, Maj, Mario |
| Předmět: |
Adult
Male medicine.drug_class Moclobemide media_common.quotation_subject Pilot Projects Neuropsychological Tests Electroencephalography Event-related potential medicine Humans Attention Biological Psychiatry media_common Depressive Disorder medicine.diagnostic_test Neuropsychology Cognition Middle Aged Antidepressive Agents Psychiatry and Mental health Electrophysiology Neuropsychology and Physiological Psychology Sedative Anesthesia Benzamides Female Arousal Cognition Disorders Psychology medicine.drug Vigilance (psychology) |
| Zdroj: | Scopus-Elsevier |
| Popis: | Quantitative electroencephalogram (QEEG) changes induced by the acute administration of moclobemide (200 mg) in patients with major depression include a transient increase in theta-activity, a slight augmentation of alpha-activity and a sustained increase in beta-activity. This QEEG profile distinguishes moclobemide from sedative antidepressants. A 42-day treatment with 400 mg/day of the drug produces a significant decrease in the late positive-complex peak latency of the event-related potentials, suggesting a positive effect on attention and cognitive functions. |
| Databáze: | OpenAIRE |
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