Manganese-Enhanced MRI of the Brain in Healthy Volunteers
| Autor: | Daniel S. Reich, D.J. Suto, Tianxia Wu, Sonya Steele, Govind Nair, B.A. Berkowitz, Jenifer Dwyer, Irene Cortese, Blake E. Dewey, D.M. Sudarshana, Alan P. Koretsky |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Exocrine gland Contrast Media Physical examination 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Anterior pituitary Basal ganglia Healthy volunteers Mangafodipir Humans Medicine Radiology Nuclear Medicine and imaging Letters Stage (cooking) Edetic Acid medicine.diagnostic_test business.industry Brain Image Enhancement Magnetic Resonance Imaging Healthy Volunteers medicine.anatomical_structure Pyridoxal Phosphate Female Choroid plexus Neurology (clinical) business Nuclear medicine 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | AJNR Am J Neuroradiol |
| ISSN: | 1936-959X 0195-6108 |
| DOI: | 10.3174/ajnr.a6152 |
| Popis: | BACKGROUND AND PURPOSE: The manganese ion is used as an intracellular MR imaging contrast agent to study neuronal function in animal models, but it remains unclear whether manganese-enhanced MR imaging can be similarly useful in humans. Using mangafodipir (Teslascan, a chelated manganese-based contrast agent that is FDA-approved), we evaluated the dynamics of manganese enhancement of the brain and glandular structures in the rostral head and neck in healthy volunteers. MATERIALS AND METHODS: We administered mangafodipir intravenously at a rate of 1 mL/minute for a total dose of 5 μmol/kg body weight. Nine healthy adult volunteers (6 men/3 women; median age, 43 years) completed baseline history and physical examination, 3T MR imaging, and blood work. MR imaging also followed mangafodipir administration at various time points from immediate to 7 days, with delayed scans at 1–3 months. RESULTS: The choroid plexus and anterior pituitary gland enhanced within 10 minutes of infusion, with enhancement persisting up to 7 and 30 days, respectively. Exocrine (parotid, submandibular, sublingual, and lacrimal) glands also enhanced avidly as early as 1 hour postadministration, generally resolving by 1 month; 3 volunteers had residual exocrine gland enhancement, which resolved by 2 months in 1 and by 3 months in the other 2. Mangafodipir did not affect clinical parameters, laboratory values, or T1-weighted signal in the basal ganglia. CONCLUSIONS: Manganese ions released from mangafodipir successfully enable noninvasive visualization of intra- and extracranial structures that lie outside the blood-brain barrier without adverse clinical effects, setting the stage for future neuroradiologic investigation in disease. |
| Databáze: | OpenAIRE |
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