Role of Impaired Glucose Tolerance in the Progression of Hypertension
| Autor: | Kazuaki Shimamoto, Shigemichi Tanaka, Shigeyuki Saitoh, Youichi Takagi |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Impaired glucose tolerance Japan Diabetes mellitus Internal medicine Glucose Intolerance Epidemiology Prevalence medicine Humans Longitudinal Studies Oral glucose tolerance Normal glucose tolerance Plasma glucose business.industry Glucose Tolerance Test Middle Aged medicine.disease Obesity Endocrinology Blood pressure Hypertension Disease Progression Female Geriatrics and Gerontology business |
| Zdroj: | Nippon Ronen Igakkai Zasshi. Japanese Journal of Geriatrics. 35:830-838 |
| ISSN: | 0300-9173 |
| DOI: | 10.3143/geriatrics.35.830 |
| Popis: | The present report describes the relationship between the glucose tolerance and hypertension surveyed in a ten-year longitudinal epidemiological study in two rural communities in Hokkaido, Japan. The 1972 subjects (928 men and 1044 women, aged 40-64, mean 51.1 +/- 7.0 years) were randomly selected in 1977 and 1978, underwent a 50-g oral glucose tolerance test (GTT) at the first year. The prevalences of borderline hypertension (BHT) and of hypertension (HT) were highest in those with diabetes mellitus (DM), followed by those with borderline diabetes (BDM) and those normal glucose tolerance (NGT). Systolic and diastolic blood pressure were significantly and positively correlated with plasma glucose levels during fasting (FPG), 60 min. after GTT (60G), and 120 min. after GTT (120G), and were ordered as follows: NGT < BDM < DM. The FPG, 60G and 120G plasma glucose levels were all significantly higher in BHT and HT than in NT. The prevalences of the progression to hypertension from non-hypertension over the ten-year follow-up period were ordered as follows: NGT < BDM < DM. Glucose levels in progression group were higher than those in non-progression group. Multiple logistic regression analysis indicated that age, glucose intolerance, systolic blood pressure, and obesity index were significant predictors of the progression to hypertension. These results indicate that impaired glucose tolerance may be associated with hypertension, and might play a role in the development of hypertension. |
| Databáze: | OpenAIRE |
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