Malignant astrocytomas of the spinal cord
| Autor: | Jeffrey H. Wisoff, Fred Epstein, Alan R. Cohen, Jeffrey C. Allen |
|---|---|
| Rok vydání: | 1989 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent medicine.medical_treatment Spinal Cord Neoplasm Population Astrocytoma Spinal Cord Glioma Postoperative Complications medicine Adjuvant therapy Humans Spinal Cord Neoplasms Child education education.field_of_study business.industry Infant medicine.disease Spinal cord Cerebrospinal Fluid Shunts Surgery Hydrocephalus Radiation therapy medicine.anatomical_structure Child Preschool Female business |
| Zdroj: | Journal of Neurosurgery. 70:50-54 |
| ISSN: | 0022-3085 |
| Popis: | ✓ The authors review their experience with the operative management of 19 consecutive cases of malignant astrocytoma of the spinal cord. There was a male to female ratio of 1.1:1, and the median age of the population was 14 years (range 1 to 32 years). The median duration of symptoms prior to definitive diagnosis was 7 weeks. Radical excision was carried out in all cases, with 18 patients (95%) receiving radiotherapy and 10 patients (53%) receiving chemotherapy as well. To date, 15 (79%) of the 19 patients in this series have died, with a median survival period of 6 months following surgery. No patient improved after operation. Hydrocephalus was present in 11 patients (58%), seven of whom underwent ventricular shunting procedures. Dissemination of disease was found in 11 patients (58%). Extraneural metastases did not occur in the absence of a ventricular shunt. The authors conclude that malignant astrocytomas of the spinal cord are heralded by a short history followed by rapid neurological deterioration and usually death. The rationale for operation is discussed, and an aggressive approach utilizing adjuvant therapy directed at the entire neuraxis is suggested. |
| Databáze: | OpenAIRE |
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