Effect of age and strain on working memory in mice as measured by win-shift paradigm
| Autor: | Christine L. Melchior, Alvin J. Glasky, Ronald F. Ritzmann, Arthur Kling |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Male
Senescence Aging Physostigmine Clinical Biochemistry Engram Models Psychological Toxicology Biochemistry Mice Behavioral Neuroscience Species Specificity medicine Animals Memory disorder Stroke Biological Psychiatry Pharmacology Working memory medicine.disease Mice Inbred C57BL Strain specificity Memory Short-Term Tacrine Psychology Neuroscience medicine.drug |
| Zdroj: | Pharmacology Biochemistry and Behavior. 44:805-807 |
| ISSN: | 0091-3057 |
| DOI: | 10.1016/0091-3057(93)90009-i |
| Popis: | Working memory is disrupted an Alzheimer's disease and stroke; therefore, any therapeutic drug should deficits in working memory. The win-shift foraging paradigm has been demostrated to be a model of working memory in rats. In the present study, this paradigm was adapted to mice because of the greater ease and economy of testing potential drugs in mice and the wider availability of strains of aged mice with naturally occuring working memory deficits. This study has demostrated strain differences in the working memory trace and that age induces a deficit that can be dete4cted at 11 months af age in mice. Tacrine and physostigmine enhance the memory trace in normal mice and physostigmine can reverse age-induced working memory deficits in subjects with mild and moderate deficits but not in subjects with severe deficits. |
| Databáze: | OpenAIRE |
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