Systematic Review and Meta-Analysis of the Blood Glutathione Redox State in Chronic Obstructive Pulmonary Disease
| Autor: | Arduino A. Mangoni, Pietro Pirina, Alessandro G. Fois, Elisabetta Zinellu, Sabrina Mellino, Panagiotis Paliogiannis, Salvatore Sotgia, Elisabetta Sotgiu, Ciriaco Carru, Angelo Zinellu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Antioxidant Physiology medicine.medical_treatment Clinical Biochemistry Pulmonary disease Review medicine.disease_cause Biochemistry Gastroenterology Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine medicine oxidative stress 030212 general & internal medicine glutathione chronic obstructive pulmonary disease (COPD) Molecular Biology chemistry.chemical_classification COPD business.industry Cell Biology Glutathione medicine.disease 030228 respiratory system chemistry Meta-analysis Thiol business Oxidative stress |
| Zdroj: | Antioxidants |
| ISSN: | 2076-3921 |
| Popis: | The aim of this systematic review and meta-analysis was to assess the blood concentrations of the total and reduced forms of the low-molecular-weight antioxidant thiol glutathione (GSH) in chronic obstructive pulmonary disease (COPD) patients in comparison to healthy individuals. A literature search was conducted in the PubMed and Web of Science databases from inception until June 2020. In the 18 studies identified (involving a total of 974 COPD patients and 631 healthy controls), the pooled reduced GSH concentrations were significantly lower in patients with COPD than controls (SMD = −3.04, 95% CI = −4.42 to −1.67; p < 0.001). By contrast, the pooled total GSH concentrations were significantly higher in patients with COPD than controls (SMD = 0.42, 95% CI = 0.11 to 0.73; p = 0.009). Our meta-analysis showed that the blood concentrations of reduced GSH, even in the presence of higher total GSH concentrations, were significantly lower in patients with COPD when compared to healthy controls. This suggests that an impaired antioxidant defense system plays an important role in the pathogenesis of COPD. |
| Databáze: | OpenAIRE |
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