The Impact of Combination Antiretroviral Therapy and its Interruption on Anxiety, Stress, Depression and Quality of Life in Thai Patients
| Autor: | Somboon Tansuphasawasdikul, Ploenchan Chetchotisakd, Jintanat Anaworanich, Phitsanu Raksakulkarn, Wisit Prasithsirikul, Sasisopin Kiertiburanakul, Kiat Ruxrungtham, Warangkana Munsakul, Sineenart Chautrakarn, Bernard Hirschel, Reto Nüesch, Angèle Gayet-Ageron |
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| Rok vydání: | 2009 |
| Předmět: |
treatment interruption
medicine.medical_specialty DASS business.industry Public Health Environmental and Occupational Health Staccato HIV infection Hospital Anxiety and Depression Scale Mental health Article Institutional repository Infectious Diseases quality of life Quality of life Virology Internal medicine medicine Anxiety ddc:576.5 medicine.symptom Psychiatry business mental health Depression (differential diagnoses) |
| Zdroj: | The Open AIDS Journal, Vol. 3 (2009) pp. 38-45 The Open AIDS Journal |
| ISSN: | 1874-6136 |
| DOI: | 10.2174/1874613600903010038 |
| Popis: | Objective:Investigation on anxiety, stress, depression, and quality of life (QoL) within STACCATO, a randomised trial of two treatment strategies: CD4 guided scheduled treatment interruption (STI) compared to continuous treatment (CT).Participants:Thai patients with HIV-infection enrolled in the STACCATO trial.Methods:Anxiety, depression assessed by the questionnairesHospital Anxiety and Depression Scale(HADS) and DASS, stress assessed by theDepression Anxiety Stress Scale(DASS), and QoL evaluated by theHIV Medical Outcome Study(MOS-HIV) questionnaires. Answers to questionnaires were evaluated at 4 time-points: baseline, 24 weeks, 48 weeks and at the end of STACCATO.Results:A total of 251 patients answered the HADS/DASS and 241 answered the MOS-HIV of the 379 Thai patients enrolled into STACCATO (66.2 and 63.6% respectively). At baseline 16.3% and 7.2% of patients reported anxiety and depression using HADS scale. Using the DASS scale, 35.1% reported mild to moderate and 9.6% reported severe anxiety; 8.8% reported mild to moderate and 2.0% reported severe depression; 42.6% reported mild to moderate and 4.8% reported severe stress. We showed a significant improvement of the MHS across time (p=0.001), but no difference between arms (p=0.17). The summarized physical health status score (PHS) did not change during the trial (p=0.15) nor between arm (p=0.45). There was no change of MHS or PHS in the STI arm, taking into account the number of STI cycle (p=0.30 and 0.57) but MHS significant increased across time-points (p=0.007).Conclusion:Antiretroviral therapy improved mental health and QOL, irrespective of the treatment strategy. |
| Databáze: | OpenAIRE |
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