Survey of severe respiratory syncytial virus infection in Kyoto Prefecture from 2003 to 2007
| Autor: | Tadaki Oomae, Toru Yamamoto, Ryuta Nisikomori, Toshio Osamura, Kenji Kishida, Yasumichi Kuwabara, Kouji Nakajima, Zenrou Kizaki, Tetsuya Yasuno, Hisato Ito, Fumiaki Nakajima, Hiroshi Komatsu, Akitoshi Nakamura, Yuichi Akiyama, Daisuke Fujiwara, Nobuyuki Kiyosawa |
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| Rok vydání: | 2010 |
| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Respiratory Syncytial Virus Infections Severity of Illness Index Sudden death Virus Japan Older patients Surveys and Questionnaires White blood cell Internal medicine medicine Hospital discharge Humans Intubation Respiratory system business.industry Incidence (epidemiology) Infant Surgery medicine.anatomical_structure Pediatrics Perinatology and Child Health Female business |
| Zdroj: | Pediatrics International. 52:273-278 |
| ISSN: | 1442-200X 1328-8067 |
| DOI: | 10.1111/j.1442-200x.2009.02962.x |
| Popis: | Background: Respiratory syncytial virus (RSV) infection in infants can develop into a severe condition. Methods: A survey of patients with severe RSV infection in hospitals in Kyoto Prefecture was performed from 2003 to 2007. Patients requiring intubation and those with cardiopulmonary arrest on arrival (CPAOA) were considered to have severe RSV infection. Results: Twenty-five patients with severe infection were identified and detailed data were available for 21 patients, of whom 18 required intubation and three had CPAOA. The male/female ratio was 12/9 and age ranged from 8 days to 19 years (average, 5.2 months; median: 2 months). At admission white blood cell count, lactate dehydrogenase (P < 0.05), and blood glucose (P < 0.01) were higher and Na was lower (P < 0.01) in the 18 patients with severe infection (excluding the CPAOA cases) compared to 18 sex- and age-matched patients with mild RSV infection. The incidence of bacterial infection was also higher in severe cases (P < 0.05). The outcome was death in four patients (19.0%, including two sudden deaths), aftereffects in two (9.5%), hospital discharge with improvement in 14 (66.7%), and an unclear outcome in one patient. Excluding the two sudden death cases, 14 of 19 patients (73.7%) were extubated within 2 weeks. The period of intubation was longer in older patients (P < 0.05). Conclusion: Because severe RSV infection led to sudden death in two cases, detection of RSV is important at admission for an infant with CPAOA. Fourteen patients (66.7%), however, had good outcomes and most patients were extubated within 2 weeks. |
| Databáze: | OpenAIRE |
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