Quantitative assessment and determinants of foveal avascular zone in healthy volunteers
| Autor: | Pei-yang Shen, Xiang-bin Kong, Yushen He, Lijun Zhou, Xiaohe Lu, Shi-gang Yan, Ling Wang, Yi Cao, Fengqun Wang |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male 0301 basic medicine Medicine (General) Fovea Centralis Prospective Clinical Research Report medicine.medical_specialty genetic structures Adolescent foveal avascular zone axial length Biochemistry Young Adult 03 medical and health sciences R5-920 0302 clinical medicine Ophthalmology Healthy volunteers Quantitative assessment medicine Humans cross-sectional study macula Fluorescein Angiography Child Aged Aged 80 and over healthy volunteer business.industry Biochemistry (medical) Retinal Vessels Cell Biology General Medicine Foveal avascular zone Axial length Optical coherence tomography angiography Middle Aged eye diseases Healthy Volunteers Cross-Sectional Studies 030104 developmental biology Child Preschool 030221 ophthalmology & optometry Female sense organs business Tomography Optical Coherence |
| Zdroj: | The Journal of International Medical Research Journal of International Medical Research, Vol 49 (2021) |
| ISSN: | 1473-2300 0300-0605 |
| Popis: | Objectives To evaluate the foveal avascular zone (FAZ) area in healthy volunteers using optical coherence tomography angiography (OCTA) and identify factors that influence the FAZ. Methods This single-center cross-sectional study included 526 eyes of 263 healthy volunteers who underwent macular scanning by Zeiss OCTA. A linear mixed model was used to investigate the effects of systemic factors (age, sex, blood pressure, height, and weight) and ocular factors (intraocular pressure, biometric parameters, and central macular thickness) on FAZ. Results In total, 520 eyes of 262 healthy volunteers were included in the analysis. The mean volunteer age was 38.59 ± 22.03 years (range, 5–84 years); 124 volunteers were male (47.33%) and 138 volunteers were female (52.67%). The mean FAZ area was 0.30 ± 0.03 mm2 (95% confidence interval [CI], 0.29–0.31 mm2). Univariate analysis showed that FAZ area was associated with age (β = 0.0011), anterior chamber depth (β = −0.0513), and axial length (β = −0.0202). Multivariate analysis showed that FAZ area was negatively correlated with axial length (β = −0.0181). Conclusions The mean FAZ area in healthy volunteers, measured using Zeiss OCTA, was 0.30 ± 0.03 mm2. Furthermore, FAZ area was negatively associated with axial length; this relationship should be considered in clinical practice. |
| Databáze: | OpenAIRE |
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