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Background: Nanotechnology plays an important role in controlling diabetes. Aim of Study: In current study, antidiabetic properties of the O/W Nano emulsion of nettle extract and cumin essential oil were evaluated. Methods:Various doses of Nettle (Urtica dioica) aqueous extract, nettle Nano emulsion, and Cuminum cyminum L essence were used in Streptozocin-induced diabetes in rats. Randall-Selitto method and Tail Flic Test were used for sciatic nerve neuropathy. Sciatic histological changes and level of Insulin like growth factor (IGF), neural growth factor (NGF), Oxidative stress, inflammatory, and apoptosis as well as blood levels of Glucose, Insulin, and inflammatory parameters were evaluated. Results: Nettle Nano emulsion, aqueous extract, and Cuminum cyminum L essence caused decreases in serum levels of glucose and cytokines, and increased insulin level while improved histological changes and reduced sciatic levels of thiobarbituric acid, reduced glutathione (GSH), TNF-a, IL-1ß, IL-6 Bax, Bcl-2, Caspase-3, and Caspase-7, and increased the oxidized level of glutathione (GSSG) and activities of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR) and levels of IGF and NGF in the sciatic tissue of diabetic rats. Conclusion: Nettle Nano emulsion, aqueous extract, and Cuminum cyminum L essence can be a good candidates for diabetic subjects. |
