Comparative study of the efficacy and safety of bromfenac, nepafenac and diclofenac sodium for the prevention of cystoid macular edema after phacoemulsification
| Autor: | Ana María Chinchurreta Capote, Mercedes Lorenzo Soto, Francisco Rivas Ruiz, Enrique Caso Peláez, Alicia García Vazquez, Group OftaCosta, Antonio Ramos Suárez |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
genetic structures medicine.medical_treatment Nepafenac 03 medical and health sciences 0302 clinical medicine Diclofenac lcsh:Ophthalmology Clinical Research Ophthalmology bromfenac medicine Macular edema nepafenac business.industry Diclofenac Sodium Phacoemulsification medicine.disease eye diseases diclofenac stomatognathic diseases Tolerability lcsh:RE1-994 Concomitant phacoemulsification 030221 ophthalmology & optometry Bromfenac business 030217 neurology & neurosurgery cystoid macular edema medicine.drug |
| Zdroj: | International Journal of Ophthalmology, Vol 11, Iss 7, Pp 1210-1216 (2018) |
| ISSN: | 2222-3959 |
| Popis: | Aim To compare the efficacy, tolerability and safety of bromfenac 0.09%, nepafenac 0.1% or diclofenac 0.1% for the prophylaxis of the cystoid macular edema (CME) after phacoemulsification. Methods Group sequential observational comparative study. After phacoemulsification, patients received two months for topical treatment of either diclofenac sodium, bromfenac or nepafenac. All patients received concomitant topical tobramycin 0.3% and topical prednisolone 1%. We measured CME using optical coherence tomography (OCT) central foveal thickness, macular thickness and total macular volume. Results We enrolled 243 patients from January to June 2015, and 35% received diclofenac, 32.9% bromfenac and 32.1% nepafenac. When we compared pre-operative to three weeks to two months, bromfenac was more effective in reducing foveal volume (21.3 and 35.4 mm3, respectively), compared with the diclofenac (1.3 and 11.5 mm3, respectively), and the nepafenac group, became more edematous 6.4 and 5.3, respectively. Totally 133 patients completed the post-surgical satisfaction questionnaire. Patients complained of eye stickiness in 13.8% whom we gave nepafenac, versus 10.3% whom we gave diclofenac sodium, and in 0 whom we gave bromfenac. Conclusion Bromfenac is the best tolerated and is more effective than diclofenac and nepafenac in reducing CME after phacoemulsification. |
| Databáze: | OpenAIRE |
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