Management of primary biliary cholangitis: results from a large real-life observational study in France and Belgium
| Autor: | and Descript, Armand Garioud, Study Groups, Jean-Pierre Arpurt, Descript, Jean Henrion, Olivier Chazouillères, Christophe Corpechot, Alexandre Pariente, Christophe Renou, Isabelle Rosa, Xavier Causse, Bertrand Hanslik |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Cholagogues and Choleretics Cirrhosis Disease Gastroenterology Belgium Internal medicine Albumins medicine Humans Stage (cooking) Retrospective Studies Hepatology medicine.diagnostic_test business.industry Liver Cirrhosis Biliary Ursodeoxycholic Acid Retrospective cohort study Bilirubin Middle Aged medicine.disease Ursodeoxycholic acid Liver biopsy Portal hypertension Female France Transient elastography business medicine.drug |
| Zdroj: | European journal of gastroenterologyhepatology. 33(1S Suppl 1) |
| ISSN: | 1473-5687 |
| Popis: | BACKGROUND AND AIMS To assess the characteristics, care, treatment response, and outcomes of primary biliary cholangitis (PBC) patients recently followed-up by hepato-gastroenterologists in various French and Belgian healthcare settings. METHODS This retrospective cohort study included patients with PBC who recently visited 79 hepato-gastroenterologists in France and Belgium. Data were collected at the time of diagnosis and at last visit and were compared according to biochemical response (BR) to ursodeoxycholic acid (UDCA) (BR), using Paris I-II criteria, and clinical outcomes. RESULTS A total of 436 patients (mean age at diagnosis 57 years, 88% females, median follow-up 5.2 years) were included. Liver biopsy, transient elastography, or none of these two procedures were performed at baseline in 216 (50%), 194 (45%), and 107 (25%) patients, respectively. Late-stage disease (histological stage III or IV, or transient elastography ≥9.6 kPa, or bilirubin >17 µM and albumin |
| Databáze: | OpenAIRE |
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