CD₈⁺ AND CD₄⁺ REGULATORY T CELLS IN COLORECTAL CANCER
| Autor: | Alexander Romanov, Anastasia Novitskaya, Zhulai Ga, Kylymbek Mamashov, Anastasia Tonkushina, Alexei Churov |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
lymphocytes
medicine.diagnostic_test Chemistry Colorectal cancer FOXP3 treg cells chemical and pharmacologic phenomena colorectal cancer medicine.disease digestive system diseases Flow cytometry Peripheral Pathogenesis Immune system foxp3 Cancer research medicine General Earth and Planetary Sciences lcsh:Q immune suppression cd₈ lcsh:Science CD8 Intracellular General Environmental Science |
| Zdroj: | Transactions of the Karelian Research Centre of the Russian Academy of Sciences, Iss 3, Pp 106-111 (2020) |
| ISSN: | 2312-4504 1997-3217 |
| Popis: | The pathogenesis of colorectal cancer (CRC) is closely associated with the development of an antitumor immune response. An important role in the regulation of the immune response is given to regulatory T cells (Treg), which may interfere with the effective recognition and elimination of tumor cells. The aim of the work was to study the content of peripheral CD8+Treg cells in patients with CRC. Analysis of the membrane and intracellular expression of markers was performed by multicolor flow cytometry. In patients with CRC, an accumulation of peripheral CD8+ and CD4+Treg lymphocytes was observed at all stages of CRC. Along with this, there was a significant decrease in the number of activated T-helpers. |
| Databáze: | OpenAIRE |
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