Peripheral ionotropic glutamate receptors contribute to Fos expression increase in the spinal cord through antidromic electrical stimulation of sensory nerves
| Autor: | Dong-Yuan Cao, Jia-Heng Li, Dilinapa Alemujiang, Yan Zhao, Fu-Quan Huo, Dan-Ni Fan, Pei-Yao He |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Male Stimulation Receptors Ionotropic Glutamate Rats Sprague-Dawley 03 medical and health sciences 0302 clinical medicine Ganglia Spinal Medicine Animals Skin Afferent Pathways business.industry General Neuroscience Glutamate receptor Spinal cord Electric Stimulation Antidromic 030104 developmental biology medicine.anatomical_structure Spinal Cord NMDA receptor Neuron business Neuroscience Proto-Oncogene Proteins c-fos 030217 neurology & neurosurgery Sensory nerve Ionotropic effect |
| Zdroj: | Neuroscience letters. 678 |
| ISSN: | 1872-7972 |
| Popis: | Previous studies have shown that peripheral ionotropic glutamate receptors are involved in the increase in sensitivity of a cutaneous branch of spinal dorsal ramus (CBDR) through antidromic electrical stimulation (ADES) of another CBDR in the adjacent segment. CBDR in the thoracic segments run parallel to each other and no synaptic contact at the periphery is reported. The present study investigated whether the increased sensitivity of peripheral sensory nerves via ADES of a CBDR induced Fos expression changes in the adjacent segments of the spinal cord. Fos expression increased in the T8 - T12 segments of the spinal cord evoked by ADES of the T10 CBDR in rats. The increased Fos expression in the T11 and T12, but not T8 - T10 spinal cord segments, was significantly blocked by local application of either N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine maleate (MK-801) or non-NMDA receptor antagonist 6,7-dinitroquinoxaline-2,3-dione (DNQX) into the receptive field of T11 CBDR. The results suggest that endogenous glutamate released by ADES of sensory nerve may bind to peripheral ionotropic glutamate receptors and activate adjacent sensory nerve endings to increase the sensitivity of the spinal cord. These data reveal the potential mechanisms of neuron activation in the spinal cord evoked by peripheral sensitization. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect