Perinatal Hypoxia Induces Anterior Chamber Changes in the Eyes of Offspring Fish
| Autor: | Wai Ping Lam, Mingwei Wang, Elizabeth Lucy Foster, David T. Yew, Maria Sen Mun Wai, Chu Yan Chan |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Programmed cell death
Intraocular pressure genetic structures Anterior Chamber Offspring Physiology Apoptosis Environment Biology Tonometry Ocular Trabecular Meshwork Edema Cornea medicine Animals Hypoxia Intraocular Pressure Poecilia Caspase 3 Anatomy Hypoxia (medical) Adaptation Physiological medicine.anatomical_structure Immunohistochemistry Female Animal Science and Zoology sense organs Trabecular meshwork medicine.symptom |
| Zdroj: | Journal of Reproduction and Development. 53:1159-1167 |
| ISSN: | 1348-4400 0916-8818 |
| DOI: | 10.1262/jrd.19018 |
| Popis: | Hypoxia is a consistent challenge for aquatic animals. It is a pressing environmental problem; hypoxia can cause cranial edema and ovarium dysfunction in fish. Although several studies have reported the effect of hypoxic insult to the visual system, the hypoxic effect on perinatal animals and in particular their offspring has yet to be elucidated. In this study, activated caspase-3 activity was investigated using immunohistochemistry in order to examine the perinatal hypoxic damage in offspring fish. Offspring were divided into groups based on different time points of sacrifice. This allowed assessment of ocular development for different age groups. The results indicated that perinatal hypoxia induced ocular developmental defects in the offspring. The defects took the form of trabecular cell death and fibre degeneration, corneal thinning and lens fibre derangement. A concomitant change in intraocular pressure was recorded by tonometer in the experimental animals compared with the controls. Further investigation should be initiated to develop strategies to prevent developmental disability due to perinatal hypoxia and to increase survivability of the offspring. |
| Databáze: | OpenAIRE |
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