Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy for Patients with Peritoneal Metastases from Endometrial Cancer
| Autor: | Paolo Sammartino, Daniele Biacchi, Athina Christopoulou, John Spiliotis, Nikolaos Kopanakis, Marialuisa Framarino dei Malatesta, Tommaso Cornali, Antonio Ciardi, Alessandra Spagnoli, Elias Efstathiou |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
medicine.medical_specialty medicine.medical_treatment 03 medical and health sciences 0302 clinical medicine Laparotomy Medicine Humans Survival rate Peritoneal Neoplasms Aged Retrospective Studies 030219 obstetrics & reproductive medicine business.industry Endometrial cancer Cancer ASO Author Reflections Retrospective cohort study Cytoreduction Surgical Procedures Hyperthermia Induced Middle Aged medicine.disease Prognosis Combined Modality Therapy Surgery Endometrial Neoplasms oncology endometrial cancer Survival Rate Chemotherapy Adjuvant 030220 oncology & carcinogenesis Chemotherapy Cancer Regional Perfusion Conventional PCI Peritoneal Cancer Index Hyperthermic intraperitoneal chemotherapy Female business Follow-Up Studies |
| Zdroj: | Annals of Surgical Oncology |
| ISSN: | 1534-4681 |
| Popis: | More information is needed for selection of patients with peritoneal metastases from endometrial cancer (EC) to undergo cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC). This study analyzed clinical, pathologic, and treatment data for patients with peritoneal metastases from EC who underwent CRS plus HIPEC at two tertiary centers. The outcome measures were morbidity, overall survival (OS), and progression-free survival (PFS) during a median 5 year follow-up period. Uni- and multivariate analyses were performed to identify significant factors related to outcome. A total of 33 patients met the inclusion criteria and completed the follow-up period. At laparotomy, the median peritoneal cancer index (PCI) was 15 (range 3–35). The CRS procedure required a mean 8.3 surgical procedures per patient, and for 22 patients (66.6%), a complete cytoreduction was achieved. The mean hospital stay was 18 days, and major morbidity developed in 21% of the patients. The operative mortality was 3%. When surgery ended, HIPEC was administered with cisplatin 75 mg/m2 for 60 min at 43 °C. During a median follow-up period of 73 months, Kaplan–Meier analysis indicated a 5 year OS of 30% (median 33.1 months) and a PFS of 15.5% (median 18 months). Multivariate analysis identified the completeness of cytoreduction (CC) score as the only significant factor independently influencing OS. Logistic regression for the clinicopathologic variables associated with complete cytoreduction (CC0) for patients with metachronous peritoneal spread from EC who underwent secondary CRS plus HIPEC identified the PCI as the only outcome predictor. For selected patients with peritoneal metastases from EC, when CRS leaves no residual disease, CRS plus HIPEC achieves outcomes approaching those for other indications such as colon and ovarian carcinoma. |
| Databáze: | OpenAIRE |
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