Practical, biochemical and evolutionary implications of the discovery of HLA class I supermotifs

Autor:	Howard M. Grey, Alessandro Sette, Ralph T. Kubo, J Sidney
Rok vydání:	1996
Předmět:	Genetics Antigen Presentation Class (set theory) Polymorphism Genetic Immunology Human leukocyte antigen Biological evolution Biology Biological Evolution Mhc polymorphism HLA Antigens Polymorphism (computer science) Phylogenetics Evolutionary biology Allele Phylogeny Protein Binding
Zdroj:	Immunology Today. 17:261-266
ISSN:	0167-5699
Popis:	Recent data suggest that the majority of HLA-A and -B alleles in human populations can be grouped into four major supertypes, as defined by their broad peptide-binding specificities. As discussed by John Sidney and colleagues, these data add to our understanding of the evolutionary and biochemical processes involved in the generation of MHC polymorphism, and suggest that HLA class I alleles may ultimately be reclassified on the basis of their peptide-binding specificities.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0a2f89da862d344a9034decde6d2b71 https://doi.org/10.1016/0167-5699(96)80542-1 Zobrazit plný text záznamu Full Text from ScienceDirect