Enhanced Induction of Apoptosis in Lung Adenocarcinoma After Preoperative Chemotherapy with Tegafur and Uracil (UFT)
| Autor: | Hiroshi Izumi, Akio Yamazaki, Atsushi Morio, Hidehiro Konno, Hideaki Miyamoto, Toshiro Futagawa, Tsumin Oh |
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| Rok vydání: | 2004 |
| Předmět: |
Male
Oncology Antimetabolites Antineoplastic medicine.medical_specialty Lung Neoplasms Apoptosis Adenocarcinoma Tegafur Preoperative care chemistry.chemical_compound Surgical oncology Internal medicine Antineoplastic Combined Chemotherapy Protocols Preoperative Care In Situ Nick-End Labeling medicine Humans Prospective Studies Uracil Aged biology business.industry General Medicine Middle Aged respiratory system medicine.disease Immunohistochemistry chemistry Chemotherapy Adjuvant Fluorouracil Ki-67 Cancer research biology.protein Drug Therapy Combination Female Surgery business medicine.drug |
| Zdroj: | Surgery Today. 34 |
| ISSN: | 1436-2813 0941-1291 |
| Popis: | To determine if the preoperative administration of tegafur and uracil (UFT) to patients with lung adenocarcinoma could induce apoptosis.We conducted a randomized prospective study on 30 patients with lung adenocarcinoma, divided into two groups of 15 patients each. One group received UFT 600 mg/day preoperatively for 7 consecutive days and a control group received no chemotherapy or radiotherapy. The apoptotic index (AI) was determined by the terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate biotin nick end-labeling (TUNEL) method. Expression of Ki-67 was examined by immunohistochemical staining. The concentration of 5-fluorouracil (5-FU) in tumor tissue was measured by chemical assay.The AI of lung adenocarcinoma cells increased significantly in the UFT-treated group but not in the control group. A significant positive correlation was seen between the AI and the 5-FU concentrations in the tumor tissue.The continuous oral administration of UFT for 7 days preoperatively resulted in enhanced apoptosis and a significant positive correlation between the AI and 5-FU concentrations in lung adenocarcinoma. Therefore, it may be possible to evaluate the effects of adjuvant chemotherapy based on the AI. |
| Databáze: | OpenAIRE |
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