Moderate vs high-load resistance training on muscular adaptations in rats
| Autor: | Fabrício Azevedo Voltarelli, Paola Sanches Cella, Camila S. Padilha, Kessi Cassiane Iarosz, Mayra T. J. Testa, Alex S. Ribeiro, Rafael Deminice, Philippe B. Guirro, Poliana Camila Marinello |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty 030226 pharmacology & pharmacy General Biochemistry Genetics and Molecular Biology Muscle hypertrophy 03 medical and health sciences 0302 clinical medicine Internal medicine Physical Conditioning Animal Medicine Animals Muscle Strength General Pharmacology Toxicology and Pharmaceutics Training load Rats Wistar Muscle Skeletal Testosterone Soleus muscle business.industry Resistance training Skeletal muscle Resistance Training General Medicine Adaptation Physiological Rats Low volume 030104 developmental biology medicine.anatomical_structure Endocrinology High load business |
| Zdroj: | Life sciences. 238 |
| ISSN: | 1879-0631 |
| Popis: | Aims The main aim of this study was to investigate the moderate versus high-load resistance training on muscle strength, hypertrophy and protein synthesis signaling in rats. Methods Twenty rats were randomly allocated into three groups as follow: control group (C, n = 6), high-load training (HL, n = 7) and moderate-load training (ML, n = 7). A ladder climb exercise was used to mimic resistance exercise. ML resistance training consisted of a moderate load, allowing performance at higher volume of load inherent to higher number of repetitions (8-16 climbing). HL resistance training consisted of progressively increase training load, with low volume of load (4-8 climbing). C group remained with physical activity restricted to their cage space. This experiment was conducted over a six-weeks period. Forty-eight hours after the last resistance training session the animals were euthanized for tissue collection. Results Both HL and ML regimens promoted similar increases in muscle strength, elevated protein synthesis signaling demonstrated by increased skeletal muscle total/phosphorylated P-70S6K ratio and similar increases in plantaris and FHL muscle hypertrophy, all compared to control. All these similarities were demonstrated even though testosterone/cortisol ratio was higher in HL group compared to ML and control. ML regimen caused higher total training volume and soleus muscle hypertrophy, which was not demonstrated in HL group. Conclusion In conclusion, results suggest that both HL and ML induce muscle hypertrophy and increase on strength in a similar way. ML moreover seems to favor slow fiber hypertrophy due the higher training volume. |
| Databáze: | OpenAIRE |
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