Ketanserin alters [3H]serotonin uptake and release in rat hypothalamus
| Autor: | Steve J. Offord, Robert O. Warwick |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Male
Serotonin medicine.medical_specialty Ketanserin Serotonin uptake medicine.drug_class Hypothalamus In Vitro Techniques Pharmacology Tritium Inhibitory postsynaptic potential Piperidines Internal medicine medicine Animals Receptor Dose-Response Relationship Drug Chemistry Rats Inbred Strains Receptor antagonist Rats Endocrinology cardiovascular system Autoreceptor Calcium Serotonin Antagonists medicine.drug |
| Zdroj: | European Journal of Pharmacology. 104:379-382 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(84)90417-5 |
| Popis: | Ketanserin, a serotonin2 receptor antagonist, evoked a dose-related non-calcium dependent release of tritium from slices of rat hypothalamus preloaded with [3H]serotonin. Concentrations of 1, 5 and 10 microM ketanserin caused a 0.5%, 64% and 110% increase, respectively, in tritium release. Chlorimipramine, a potent inhibitor of the serotonin uptake mechanism, did not alter the spontaneous release of tritium. In addition, 5 microM ketanserin reduced high affinity uptake of 0.1 microM [3H]serotonin into rat hypothalamus slices by 36%. These data suggest ketanserin possesses 'amphetamine-like' releasing activity and an uptake inhibitory action on serotonin nerve terminals. Both of these properties could mask 5-HT receptor antagonism in vitro and in vivo. |
| Databáze: | OpenAIRE |
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