Design of antibacterial apatitic composite cement loaded with Ciprofloxacin: Investigations on the physicochemical Properties, release Kinetics, and antibacterial activity

Autor: Hanaa Mabroum, Hamza Elbaza, Hicham Ben Youcef, Hassane Oudadesse, Hassan Noukrati, Allal Barroug
Přispěvatelé: Université Mohammed VI Polytechnique [Ben Guerir] (UM6P), Université Cadi Ayyad [Marrakech] (UCA), Institut des Sciences Chimiques de Rennes (ISCR), Université de Rennes (UR)-Institut National des Sciences Appliquées - Rennes (INSA Rennes), Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Ecole Nationale Supérieure de Chimie de Rennes (ENSCR)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), This work was supported by the OCP Foundation (Morocco) through the APPHOS Program (project ID: MAT-BAR-01/2017).
Rok vydání: 2023
Předmět:
Zdroj: International Journal of Pharmaceutics
International Journal of Pharmaceutics, 2023, 637, pp.122861. ⟨10.1016/j.ijpharm.2023.122861⟩
ISSN: 0378-5173
DOI: 10.1016/j.ijpharm.2023.122861
Popis: International audience; This work aims to develop an injectable and antibacterial composite cement for bone substitution and prevention/treatment of bone infections. This cement is composed of calcium phosphate, calcium carbonate, bioactive glass, sodium alginate, and ciprofloxacin. The effect of ciprofloxacin on the microstructure, chemical composition, setting properties, cohesion, injectability, and compressive strength was investigated. The in vitro drug release kinetics and the antibacterial activity of ciprofloxacin-loaded composites against staphylococcus aureus and Escherichia coli pathogens were investigated. XRD and FTIR analysis demonstrated that the formulated cements are composed of a nanocrystalline carbonated apatite analogous to the mineral part of the bone. The evaluation of the composite cement’s properties revealed that the incorporation of 3 and 9 wt% of ciprofloxacin affects the microstructural and physicochemical properties of the cement, resulting in a prolonged setting time, and a slight decrease in injectability and compressive strength. The in vitro drug release study revealed sustained release profiles over 18 days. The amounts of ciprofloxacin released per day (0.2 -15.2 mg/L) depend on the cement composition and the amount of ciprofloxacin incorporated. The antibacterial activity of ciprofloxacin-loaded cement composites attested to their effectiveness to inhibit the growth of Staphylococcus aureus and Escherichia coli.
Databáze: OpenAIRE
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