Prolonged intravenous immunoglobulin treatment in very low birth weight infants with late onset sepsis
| Autor: | Aldo Bancalari, P Martínez, T Muñoz |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class medicine.medical_treatment Birth weight Antibiotics Dose-Response Relationship Immunologic Infant Premature Diseases Gastroenterology Immunoglobulin G Sepsis 03 medical and health sciences 0302 clinical medicine Immune system 030225 pediatrics Internal medicine medicine Staphylococcus epidermidis Humans Immunologic Factors Infant Very Low Birth Weight 030219 obstetrics & reproductive medicine Duration of Therapy biology business.industry Infant Newborn Immunoglobulins Intravenous Infant medicine.disease Low birth weight Treatment Outcome Pediatrics Perinatology and Child Health biology.protein Female medicine.symptom Antibody Neonatal Sepsis business Adjuvant Infant Premature |
| Zdroj: | Journal of neonatal-perinatal medicine. 13(3) |
| ISSN: | 1878-4429 |
| Popis: | BACKGROUND: Neonatal infections are a leading cause of morbi-mortality despite advances in antimicrobials and neonatal care. Preterm infants have greater susceptibility to sepsis due to an immature immune system and lower immunoglobulin levels. Intravenous immunoglobulins (IVIG) have been used in several studies as an adjuvant treatment to improve this physiological immune deficiency, with different outcomes. METHODS: Very low birth weight (VLBW) infants who developed sepsis in the neonatal ICU were studied. They were randomly divided in 2 groups: one group was treated with antibiotics (Group I), and the other received antibiotics plus a 500 mg/kg/day of IVIG during 7 days (Group II). Serum IgG concentration was determined at initiation, during and after treatment Group I, and daily during the 7 days of therapy in Group II. RESULTS: The baseline IgG concentration in group II was 486 g/dL, and increased to 852 mg/dL after the first dose of IVIG (p |
| Databáze: | OpenAIRE |
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