Two parallel worlds of memory T cells
| Autor: | Jacqueline Berner, Dietmar Zehn, Talyn Chu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Immunology Immunological memory Biology CD8-Positive T-Lymphocytes complex mixtures Article 03 medical and health sciences 0302 clinical medicine Text mining medicine Immunology and Allergy Humans integumentary system business.industry Lymphocyte differentiation Contrast (music) Phenotype 030104 developmental biology medicine.anatomical_structure Lymphocyte activation business human activities Memory T cell Neuroscience Immunologic Memory 030215 immunology |
| Zdroj: | Nature immunology |
| ISSN: | 1529-2916 |
| Popis: | T cell memory relies on the generation of antigen-specific progenitors with stem-like properties. However, the identity of these progenitors has remained unclear, precluding a full understanding of the differentiation trajectories that underpin the heterogeneity of antigen-experienced T cells. We used a systematic approach guided by single-cell RNA sequencing data to map the organizational structure of the human CD8+ memory T cell pool under physiological conditions. We identified two previously unrecognized subsets of clonally, epigenetically, functionally, phenotypically, and transcriptionally distinct stem-like CD8+ memory T cells. Progenitors lacking the inhibitory receptors programmed death-1 (PD-1) and T cell immunoreceptor with Ig and ITIM domains (TIGIT) were committed to a functional lineage, whereas progenitors expressing PD-1 and TIGIT were committed to a dysfunctional, exhausted-like lineage. Collectively, these data revealed the existence of parallel differentiation programs in the human CD8+ memory T cell pool, with potentially broad implications for the development of immunotherapies and vaccines. |
| Databáze: | OpenAIRE |
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