Multiple opioid receptors mediate the hypotensive response induced by central 5-HT3 receptor stimulation
| Autor: | V.F. Ribeiro, Josmara Bartolomei Fregoneze, E. De Castro e Silva, Hilda Silva Ferreira, E.F. Oliveira |
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| Rok vydání: | 2011 |
| Předmět: |
Male
medicine.medical_specialty medicine.drug_class Narcotic Antagonists Central nervous system Biguanides Blood Pressure Stimulation Pharmacology Serotonergic 5-HT3 receptor Cellular and Molecular Neuroscience Endocrinology Heart Rate Opioid receptor Internal medicine medicine Animals Serotonin 5-HT3 Receptor Antagonists Rats Wistar Receptor 5-HT receptor biology Naloxone Endocrine and Autonomic Systems business.industry Serotonin 5-HT3 Receptor Agonists General Medicine Ondansetron Naltrexone Rats medicine.anatomical_structure Neurology Opioid Receptors Opioid biology.protein Hypotension Receptors Serotonin 5-HT3 business medicine.drug |
| Zdroj: | Neuropeptides. 45:219-227 |
| ISSN: | 0143-4179 |
| DOI: | 10.1016/j.npep.2011.03.004 |
| Popis: | The aim of the present work was to investigate the role of brain μ, κ and δ opioid receptors in the central serotonergic mechanisms regulating blood pressure in rats. The data obtained show that: (1) pharmacological activation of central 5-HT 3 receptors yields a significant decrease in blood pressure; (2) the blockade of those receptors by a selective antagonist induces an acute hypertensive response; (3) the pharmacological blockade of central opioid receptors by three different opioid antagonists exhibiting variable degrees of selectivity to μ, κ and δ opioid receptors always suppressed the hypotensive response induced by central 5-HT 3 receptor stimulation; (4) the blockade of opioid receptors by the same opioid antagonists that impaired the hypotensive effect of central 5-HT 3 receptor stimulation failed to modify blood pressure in animals not submitted to pharmacological manipulations of central 5-HT 3 receptor function. It is shown that a 5-HT 3 receptor-dependent mechanism seems to be part of the brain serotonergic system that contributes to cardiovascular regulation since the hypertensive response observed after ondansetron administration indicates that central 5-HT 3 receptors exert a tonic inhibitory drive on blood pressure. Furthermore, the data obtained here clearly indicate that the hypotensive response observed after pharmacological stimulation of central 5-HT 3 receptors depends on the functional integrity of brain μ, κ and δ opioid receptors, suggesting that a functional interaction between serotonergic and opiatergic pathways in the brain is part of the complex, multifactorial system that regulates blood pressure in the central nervous system. |
| Databáze: | OpenAIRE |
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