Degradation of poly(methyl 2-cyanoacrylates)

Autor:	Fred Leonard, Clarence W. R. Wade
Rok vydání:	1972
Předmět:	chemistry.chemical_classification Carbon Isotopes Nitrates Polymers Chemistry Hydrolysis Radiochemistry Biomedical Engineering Esters Polymer Urine Cyanoacrylates Biomaterials chemistry.chemical_compound Dogs Monomer In vivo Urea Animals Degradation (geology) Nuclear chemistry
Zdroj:	Journal of Biomedical Materials Research. 6:215-220
ISSN:	1097-4636 0021-9304
DOI:	10.1002/jbm.820060310
Popis:	Methyl 2-cyanoacrylate-2-14C, -3-14C and -14CN tagged monomers were im planted subcutaneously in mongrel dogs and their urine assayed for radioactivity. The results show that the urea from the -3-14C was radioactive and radioactive acidic components, as well as neutral moieties, were present. Urea recovered from the urine of animals in which the -2-14C and -14CN methyl 2-cyanoacrylate were implanted was only very slightly radioactive. The data are consistent with the hypothesis that hydrolytic chain scission and ester hydrolysis may be involved in the degradation of 2-cyanoacrylates in vivo.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0953a099fc13e072daf46e5a672b237 https://doi.org/10.1002/jbm.820060310 Zobrazit plný text záznamu Plný text