Synthesis of Enantiopure 2-C-Methyl-d-erythritol 4-Phosphate and 2,4-Cyclodiphosphate from d-Arabitol

Autor:	Marek Urbansky, Robert M. Coates, Jacob D. Surjan, Chad E. Davis
Rok vydání:	2003
Předmět:	2-C-methyl-D-erythritol-4-phosphate Stereochemistry Chemistry Organic Chemistry D-arabitol Stereoisomerism Biochemistry Isoprenoid biosynthesis Erythritol Sugar Alcohols Enantiopure drug Models Chemical Sugar Phosphates Physical and Theoretical Chemistry
Zdroj:	Organic Letters. 6:135-138
ISSN:	1523-7052 1523-7060
DOI:	10.1021/ol0362562
Popis:	[reaction: see text] Two key intermediates of the newly discovered mevalonate-independent pathway for isoprenoid biosynthesis were prepared. Optically pure 2-C-methyl-D-erythritol 4-phosphate and 2,4-cyclodiphosphate were chemically synthesized from D-arabitol using a convenient benzylidene and tert-butyldimethylsilyl protection of polyhydroxylated intermediates. The new scheme offers a straightforward route to analogues and labeled forms.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c092d0d0fe22274dc7949cb71095a436 https://doi.org/10.1021/ol0362562 Zobrazit plný text záznamu