Transmission-blocking Effects of Primaquine and Methylene Blue Suggest Plasmodium falciparum Gametocyte Sterilization Rather Than Effects on Sex Ratio

Autor: John S. Bradley, Michael J. Delves, Teun Bousema, Almahamoudou Mahamar, Thomas S. Churcher, Harouna M Soumare, Alassane Dicko, Chris Drakeley, Halimatou Diawara, Roly Gosling, Michelle E. Roh
Přispěvatelé: PATH-Program for Appropriate Technology in Health, Medical Research Council (MRC)
Rok vydání: 2019
Předmět:
0301 basic medicine
Male
Primaquine
Mali
chemistry.chemical_compound
Malaria
Falciparum
Child
11 Medical and Health Sciences
Plasmodium falciparum gametocyte
biology
treatment
transmission
Middle Aged
3. Good health
Infectious Diseases
Child
Preschool
Female
Sex ratio
Methylene blue
medicine.drug
Microbiology (medical)
Adult
Adolescent
030106 microbiology
Plasmodium falciparum
malaria
Microbiology
Andrology
03 medical and health sciences
Antimalarials
Young Adult
medicine
Gametocyte
Animals
Humans
infectiousness
Sex Ratio
business.industry
fungi
Sterilization
Sterilization (microbiology)
06 Biological Sciences
medicine.disease
biology.organism_classification
Methylene Blue
030104 developmental biology
Culicidae
lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4]
chemistry
anopheles
Brief Reports
business
Malaria
Zdroj: Clinical Infectious Diseases
Clinical Infectious Diseases, 69, 8, pp. 1436-1439
Clinical Infectious Diseases, 69, 1436-1439
Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
ISSN: 1058-4838
DOI: 10.1093/cid/ciz134
Popis: Contains fulltext : 208938.pdf (Publisher’s version ) (Open Access) Gametocyte density and sex ratio can predict the proportion of mosquitoes that will become infected after feeding on blood of patients receiving nongametocytocidal drugs. Because primaquine and methylene blue sterilize gametocytes before affecting their density and sex ratio, mosquito feeding experiments are required to demonstrate their early transmission-blocking effects.
Databáze: OpenAIRE
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