Brain abnormalities in children and adolescents with chronic kidney disease
| Autor: | Mina Matsuda-Abedini, Kevin Fitzpatrick, Waverly Harrell, Stephen R. Hooper, Steven P. Miller, Ken Poskitt, Bruce Bjornson, Aysenil Belger, Debbie S. Gipson |
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| Rok vydání: | 2018 |
| Předmět: |
Male
medicine.medical_specialty Internal capsule Adolescent 030232 urology & nephrology urologic and male genital diseases Article Cohort Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Fractional anisotropy medicine Humans Prospective Studies Risk factor Child Prospective cohort study Stroke Brain Diseases medicine.diagnostic_test business.industry Brain Magnetic resonance imaging medicine.disease Magnetic Resonance Imaging White Matter 3. Good health Cross-Sectional Studies Diffusion Tensor Imaging Case-Control Studies Pediatrics Perinatology and Child Health Cardiology Anisotropy Kidney Failure Chronic Female business 030217 neurology & neurosurgery Kidney disease Diffusion MRI |
| Zdroj: | Pediatric research |
| ISSN: | 1530-0447 0031-3998 |
| Popis: | Background Chronic kidney disease (CKD) is a risk factor for vascular disease and stroke. The spectrum of brain injury and microstructural white matter abnormalities in children with CKD is largely unknown. Methods Cross sectional study at two North American pediatric hospitals. A cohort of 49 children, 29 with CKD, including renal transplant (mean age 14.4 ± 2.9 years; range 9–18), and 20 healthy controls (mean age 13.7 ± 3.1 years; range 9–18) had their conventional brain magnetic resonance images (MRIs) reviewed by one neuroradiologist to determine the prevalence of brain injury. Fractional anisotropy (FA) maps calculated from diffusion tensor imaging (DTI) were generated to compare white matter microstructure in CKD compared to controls, using tract-based spatial statistics (TBSS). Results Focal and multifocal white matter injury was seen on brain MRI in 6 children with CKD (21%). Relative to controls, CKD subjects showed reduced white matter fractional anisotropy and increased mean diffusivity and radial diffusivity in the anterior limb of the internal capsule, suggestive of abnormal myelination. Conclusion Cerebral white matter abnormalities, including white matter injury, are under-recognized in pediatric CKD patients. Brain imaging studies through progression of CKD are needed to determine the timing of white matter injury and any potentially modifiable risk factors. |
| Databáze: | OpenAIRE |
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