Pathogenesis of ANCA-Associated Vasculitis: New Possibilities for Intervention
| Autor: | Wayel H. Abdulahad, Peter Heeringa, Coen A. Stegeman, Cees G. M. Kallenberg |
|---|---|
| Přispěvatelé: | Groningen Kidney Center (GKC), Translational Immunology Groningen (TRIGR) |
| Rok vydání: | 2013 |
| Předmět: |
Pathology
Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis T-Lymphocytes Complement Pathway Alternative Microscopic Polyangiitis ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES Churg-Strauss Syndrome T-CELL-ACTIVATION Glomerulonephritis immune system diseases Proteinase 3 Medicine skin and connective tissue diseases antibodies to proteinase 3 (PR3-ANCA) pathogenesis HUMAN NEUTROPHILS Staphylococcal Infections Silicon Dioxide POLYANGIITIS WEGENERS Nephrology Experimental pathology CRESCENTIC GLOMERULONEPHRITIS Microscopic polyangiitis Granulomatosis with polyangiitis Vasculitis INTERACTIONS IN-VIVO medicine.medical_specialty Myeloblastin Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis SMALL-VESSEL VASCULITIS WEGENERS-GRANULOMATOSIS Antigen Humans Genetic Predisposition to Disease cardiovascular diseases Peroxidase Anti-neutrophil cytoplasmic antibody PROTEINASE-3 PR3 business.industry microscopic polyangiitis (MPA) Histocompatibility Antigens Class II Autoantibody antibodies to myeloperoxidase (MPO-ANCA) medicine.disease ENDOTHELIAL-CELLS Polyarteritis Nodosa respiratory tract diseases Immunology Gene-Environment Interaction granulomatosis with polyangiitis (GPA) business |
| Zdroj: | American Journal of Kidney Diseases, 62(6), 1176-1187. W B SAUNDERS CO-ELSEVIER INC |
| ISSN: | 0272-6386 |
| DOI: | 10.1053/j.ajkd.2013.05.009 |
| Popis: | The antineutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) comprise granulomatosis with polyangiitis (GPA), primarily associated with antibodies to proteinase 3 (PR3-ANCA); microscopic polyangiitis (MPA); and eosinophilic granulomatosis with polyangiitis (EGPA), both principally associated with antibodies to myeloperoxidase (MPO-ANCA). Genetic and environmental factors are involved in their etiopathogenesis, with a possible role for silica exposure in AAVs and Staphylococcus aureus infection in GPA. The distinct associations of PR3-ANCA and MPO-ANCA with different HLA class II antigens, which are stronger than those with the associated diseases, suggest a pathogenic role for those ANCAs and indicate that GPA and MPA are different diseases. Both in vitro and in vivo experimental data have shown that MPO-ANCA can induce necrotizing small-vessel vasculitis and glomerulonephritis. The additional role of the alternative pathway of complement activation has been demonstrated in human and experimental pathology. Also, T cells seem to be involved in lesion development, particularly in the kidney. Granuloma formation, as seen in PR3-ANCA-associated GPA, is not well explained by the presence of autoantibodies in experimental models. Here, T cells seem crucial. Recently obtained insights into the pathogenesis of AAVs have led to more targeted treatment of these life-threatening diseases. (C) 2013 by the National Kidney Foundation, Inc. |
| Databáze: | OpenAIRE |
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