Endocrine disrupting potential of replacement flame retardants – Review of current knowledge for nuclear receptors associated with reproductive outcomes

Autor: Johanna Barthelemy-Berneron, Lola Bajard, Vicente Mustieles, Ludek Blaha, Stéphane Jomini, Mariana F. Fernández, Chander K. Negi, Lisa Emily Melymuk
Přispěvatelé: Research Centre for Toxic Compounds in the Environment [Brno] (RECETOX / MUNI), Faculty of Science [Brno] (SCI / MUNI), Masaryk University [Brno] (MUNI)-Masaryk University [Brno] (MUNI), CIBER de Epidemiología y Salud Pública (CIBERESP), Direction de l'Evaluation des Risques (DER), Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (ANSES), The research was supported by funding from the European Unionś Horizon 2020 Research and Innovation Programme under grant agreements No 733032 (HBM4EU), No. 859891 (PRORISK), and No. 857560 (CETOCOEN EXCELLENCE Teaming 2 project). The RECETOX Research infrastructure was further supported by the Czech Ministry of Education, Youth and Sports (LM2018121, CZ02.1.01/0.0/0.0/18_046/0015975)., European Project: 733032,H2020,HBM4EU(2017)
Rok vydání: 2021
Předmět:
animal structures
010504 meteorology & atmospheric sciences
medicine.drug_class
Endocrine disruption
Population
Receptors
Cytoplasmic and Nuclear
MESH: Receptors
Cytoplasmic and Nuclear
Endocrine Disruptors
010501 environmental sciences
MESH: Flame Retardants
MESH: Reproduction
Bioinformatics
Flame retardants
01 natural sciences
Phosphates
Nuclear receptors
Steroid hormones
Emerging contaminants
ToxCast
medicine
Humans
Endocrine system
GE1-350
education
Flame Retardants
0105 earth and related environmental sciences
General Environmental Science
education.field_of_study
MESH: Humans
business.industry
Reproduction
Research needs
MESH: Endocrine Disruptors
3. Good health
Environmental sciences
Rapid identification
Nuclear receptor
Estrogen
[SDV.TOX]Life Sciences [q-bio]/Toxicology
MESH: Phosphates
business
Systematic search
Zdroj: Environment International
Environment International, Elsevier, 2021, 153, pp.106550. ⟨10.1016/j.envint.2021.106550⟩
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Environment International, Vol 153, Iss, Pp 106550-(2021)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Environment International, 2021, 153, pp.106550. ⟨10.1016/j.envint.2021.106550⟩
ISSN: 0160-4120
Popis: The research was supported by funding from the European Unions ' Horizon 2020 Research and Innovation Programme under grant agreements No 733032 (HBM4EU) , No. 859891 (PRORISK) , and No. 857560 (CETOCOEN EXCELLENCE Teaming 2 project) . The RECETOX Research infrastructure was further supported by the Czech Ministry of Education, Youth and Sports (LM2018121; CZ02.1.01/0.0/0.0/18_046/0015975) .
Background and aim: Endocrine disrupting chemicals (EDCs) constitute a major public health concern because they can induce a large spectrum of adverse effects by interfering with the hormonal system. Rapid identification of potential EDCs using in vitro screenings is therefore critical, particularly for chemicals of emerging concerns such as replacement flame retardants (FRs). The review aimed at identifying (1) data gaps and research needs regarding endocrine disrupting (ED) properties of replacement FRs and (2) potential EDCs among these emerging chemicals. Methods: A systematic search was performed from open literature and ToxCast/Tox21 programs, and results from in vitro tests on the activities of 52 replacement FRs towards five hormone nuclear receptors (NRs) associated with reproductive outcomes (estrogen, androgen, glucocorticoid, progesterone, and aryl hydrocarbon receptors) were compiled and organized into tables. Findings were complemented with information from structure-based in silico model predictions and in vivo information when relevant. Results: For the majority of the 52 replacement FRs, experimental in vitro data on activities towards these five NRs were either incomplete (15 FRs) or not found (24 FRs). Within the replacement FRs for which effect data were found, some appeared as candidate EDCs, such as triphenyl phosphate (TPhP) and tris(1,3-dichloropropyl) phosphate (TDCIPP). The search also revealed shared ED profiles. For example, anti-androgenic activity was reported for 19 FRs and predicted for another 21 FRs. Discussion: This comprehensive review points to critical gaps in knowledge on ED potential for many replacement FRs, including chemicals to which the general population is likely exposed. Although this review does not cover all possible characteristics of ED, it allowed the identification of potential EDCs associated with reproductive outcomes, calling for deeper evaluation and possibly future regulation of these chemicals. By identifying shared ED profiles, this work also raises concerns for mixture effects since the population is co-exposed to several FRs and other chemicals.
European Commission 733032 859891 857560
Ministry of Education, Youth & Sports - Czech Republic LM2018121 CZ02.1.01/0.0/0.0/18_046/0015975
Databáze: OpenAIRE
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