The interplay between host genetics and the gut microbiome reveals common and distinct microbiome features for complex human diseases
| Autor: | Chu-wen Ling, Zelei Miao, Ting-yu Sun, Ju-Sheng Zheng, Jun Wang, Jian Yang, Zengliang Jiang, Fengzhe Xu, Wanglong Gou, Yuanqing Fu, Menglei Shuai, Yu-ming Chen |
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| Přispěvatelé: | Zheng, Ju-Sheng [0000-0001-6560-4890], Apollo - University of Cambridge Repository |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Microbiology (medical)
Adult Male medicine.medical_specialty Disease-microbiome features Disease Gut flora Microbiology Bidirectional Mendelian randomization analyses lcsh:Microbial ecology 03 medical and health sciences 0302 clinical medicine Medical microbiology Alcaligenaceae Leukemia Myelogenous Chronic BCR-ABL Positive Mendelian randomization medicine SNP Animals Humans Lupus Erythematosus Systemic Microbiome 030304 developmental biology Aged Genetics 0303 health sciences Gut microbiome biology Research Heritability Middle Aged biology.organism_classification Gastrointestinal Microbiome Host genetics Case-Control Studies lcsh:QR100-130 Female 030217 neurology & neurosurgery Genome-Wide Association Study |
| Zdroj: | Microbiome Microbiome, Vol 8, Iss 1, Pp 1-14 (2020) |
| ISSN: | 2049-2618 |
| Popis: | Background Interest in the interplay between host genetics and the gut microbiome in complex human diseases is increasing, with prior evidence mainly being derived from animal models. In addition, the shared and distinct microbiome features among complex human diseases remain largely unclear. Results This analysis was based on a Chinese population with 1475 participants. We estimated the SNP-based heritability, which suggested that Desulfovibrionaceae and Odoribacter had significant heritability estimates (0.456 and 0.476, respectively). We performed a microbiome genome-wide association study to identify host genetic variants associated with the gut microbiome. We then conducted bidirectional Mendelian randomization analyses to examine the potential causal associations between the gut microbiome and complex human diseases. We found that Saccharibacteria could potentially decrease the concentration of serum creatinine and increase the estimated glomerular filtration rate. On the other hand, atrial fibrillation, chronic kidney disease and prostate cancer, as predicted by host genetics, had potential causal effects on the abundance of some specific gut microbiota. For example, atrial fibrillation increased the abundance of Burkholderiales and Alcaligenaceae and decreased the abundance of Lachnobacterium, Bacteroides coprophilus, Barnesiellaceae, an undefined genus in the family Veillonellaceae and Mitsuokella. Further disease-microbiome feature analysis suggested that systemic lupus erythematosus and chronic myeloid leukaemia shared common gut microbiome features. Conclusions These results suggest that different complex human diseases share common and distinct gut microbiome features, which may help reshape our understanding of disease aetiology in humans. |
| Databáze: | OpenAIRE |
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