Bioenergetic-active materials enhance tissue regeneration by modulating cellular metabolic state
| Autor: | Jean-Philippe St-Pierre, Molly M. Stevens, Mingle Cai, Jianglin Wang, Haoming Liu, Hélène Autefage, Shengmin Zhang, Mads Sylvest Bergholt, Yingying Du, Gaojie Yang |
|---|---|
| Přispěvatelé: | Medical Research Council (MRC) |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Scaffold
Bone Regeneration Bioenergetics Anabolism Chemical Phenomena Materials Science Biocompatible Materials 02 engineering and technology Mitochondrion ACTIVATION 03 medical and health sciences chemistry.chemical_compound MITOCHONDRIA Tissue engineering Biosynthesis Animals Regeneration Health and Medicine MINERALIZATION Bone regeneration Research Articles 030304 developmental biology REPAIR 0303 health sciences Science & Technology Multidisciplinary Tissue Engineering Tissue Scaffolds Regeneration (biology) Spectrum Analysis SciAdv r-articles MECHANICAL-PROPERTIES 021001 nanoscience & nanotechnology COLLAGEN Cell biology Multidisciplinary Sciences ATP chemistry Science & Technology - Other Topics GROWTH Rabbits 0210 nano-technology Energy Metabolism BONE-FORMATION Metabolic Networks and Pathways NUCLEATION Research Article |
| Zdroj: | Science Advances |
| ISSN: | 2375-2548 |
| Popis: | We report a biodegradable synthetic material that opens a door to repair damaged tissue via boosting cellular energy metabolism. Cellular bioenergetics (CBE) plays a critical role in tissue regeneration. Physiologically, an enhanced metabolic state facilitates anabolic biosynthesis and mitosis to accelerate regeneration. However, the development of approaches to reprogram CBE, toward the treatment of substantial tissue injuries, has been limited thus far. Here, we show that induced repair in a rabbit model of weight-bearing bone defects is greatly enhanced using a bioenergetic-active material (BAM) scaffold compared to commercialized poly(lactic acid) and calcium phosphate ceramic scaffolds. This material was composed of energy-active units that can be released in a sustained degradation-mediated fashion once implanted. By establishing an intramitochondrial metabolic bypass, the internalized energy-active units significantly elevate mitochondrial membrane potential (ΔΨm) to supply increased bioenergetic levels and accelerate bone formation. The ready-to-use material developed here represents a highly efficient and easy-to-implement therapeutic approach toward tissue regeneration, with promise for bench-to-bedside translation. |
| Databáze: | OpenAIRE |
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